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GlossaryCaveolin-1

protein involved in cell membrane structure and signaling

Caveolin-1 (CAV1) is a protein that plays a crucial role in the formation of caveolae, which are small invaginations on the cell membrane involved in various cellular processes such as signal transduction and endocytosis. It is also important in regulating lipid metabolism and maintaining cellular structure. In the context of hair biology, alterations in Caveolin-1 expression have been linked to conditions like alopecia, where hair loss occurs.

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A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

research A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

4 citations , May 2021 in “Biomedicines”

Targeting the protein Caveolin-1 might help treat a type of scarring hair loss called Frontal Fibrosing Alopecia.

Deregulation of Toll Like Receptor Signaling and Association With Caveolin-1 in Lichen Planopilaris Reveals a Novel Mechanism in Pathogenesis of Scarring Alopecia

research 1425 Deregulation of toll like receptor signaling and association with caveolin-1 in lichen planopilaris reveals a novel mechanism in pathogenesis of scarring alopecia

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study suggests that changes in immune system receptors and their interaction with a cell component may be important in the development of a type of hair loss condition.

Spatial Transcriptomic Analysis of Imiquimod-Treated Mouse Skin Reveals Deregulation of Lipid Raft-Associated Markers Reversible by Caveolin Scaffolding Domain Peptide

research 1619 Spatial transcriptomic analysis of imiquimod-treated mouse skin reveals deregulation of lipid raft-associated markers which could be reversed by re-introduction of caveolin scaffolding domain peptide

April 2023 in “Journal of Investigative Dermatology”

The research found that a protein called caveolin-1 is reduced in psoriasis, but reintroducing it can help alleviate some psoriasis symptoms.

research Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells

1 citations , January 2022 in “BMC Genomic Data”

The study found that androgen receptors in skin cells mainly affect the focal adhesion pathway and control the caveolin-1 gene, with implications for new treatments for related diseases.

Comparative Transcriptome Profiling of Hair Follicles from Forest Musk Deer at Different Stages

research Comparative transcriptome profiling of hair follicles from forest musk deer (Moschus berezovskii) at different stages

November 2022 in “Research Square (Research Square)”

The research provides insights into hair follicle growth in forest musk deer by identifying key genes and pathways involved.

Comprehensive Transcriptome Data to Identify Downstream Genes of Testosterone Signaling in Dermal Papilla Cells

research Comprehensive transcriptome data to identify downstream genes of testosterone signalling in dermal papilla cells

November 2022 in “Scientific Data”

The research identified genes and non-coding RNAs in cells that could be affected by testosterone, which may help understand hair loss and prostate cancer.

research Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway

January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology”

Minoxidil increases cell layer permeability by reducing tight junction proteins and raising ROS levels.

research 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs

July 2024 in “Journal of Investigative Dermatology”

Bioengineered skin models aging well, useful for studying aging and testing treatments.

research Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

October 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Musk glands and skin in Chinese forest musk deer are closely related and share many genes.

COVID-19 and Sex Differences: Mechanisms and Biomarkers

research COVID-19 and Sex Differences

185 citations , August 2020 in “Mayo Clinic Proceedings”

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

The Relationship Between Keratin 18 and Epithelial-Derived Tumors: As a Diagnostic Marker, Prognostic Marker, and Its Role in Tumorigenesis

research The relationship between keratin 18 and epithelial-derived tumors: as a diagnostic marker, prognostic marker, and its role in tumorigenesis

October 2024 in “Frontiers in Oncology”

Keratin 18 helps diagnose and predict cancer progression and affects cancer growth and spread.

research Evaluation of oxidative stress, 3-Nitrotyrosine, and HMGB-1 levels in patients with wet type Age-Related Macular Degeneration

5 citations , September 2021 in “Journal of Medical Biochemistry”

wAMD patients have higher oxidative stress, suggesting antioxidant treatment may help.

research Novel Effect of Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) on Hair Follicle Cells Proliferation and Hair Growth

1 citations , August 2023 in “Biomolecules & therapeutics”

HAPLN1 can promote hair growth and may help treat hair loss.

research Vitamin D Receptor: New Assignments for an Already Busy Receptor

510 citations , August 2006 in “Endocrinology”

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

research Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress

88 citations , August 2014 in “PLOS genetics”

Syndecan-1 is essential for maintaining skin fat and preventing cold stress.

research Molecular Genetic and Endocrine Mechanisms of Hair Growth

51 citations , January 2003 in “Hormone Research in Paediatrics”

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

research MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata

1 citations , December 2023 in “International journal of molecular sciences”

miR-199a-3p controls hair growth and is linked to alopecia areata.

research Exploring the Role of GLP‐1 Agents in Managing Diabetic Foot Ulcers: A Narrative and Systematic Review

September 2025 in “Wound Repair and Regeneration”

GLP-1 receptor agonists may help manage and prevent diabetic foot ulcers.

research Minireview: vitamin D receptor: new assignments for an already busy receptor. - eScholarship

December 2006

The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.

research Food and medicine homology: a potential nutritional intervention strategy for post-acute COVID-19 syndrome

1 citations , July 2025 in “Frontiers in Pharmacology”

FMH foods may help manage post-acute COVID-19 symptoms safely and easily.

research The role of integrin alphavbeta6 in impaired wound healing and hair follicle regeneration

January 2010

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.

research 3D spheroid culture synchronizes heterogeneous MSCs into an immunomodulatory phenotype with enhanced anti-inflammatory effects

13 citations , August 2024 in “iScience”

3D spheroid culture makes stem cells better at reducing inflammation.