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Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research 황백(黃柏)이 전립선비대증(前立腺肥大症) Rat에 미치는 영향

January 2010 in “Journal of Oriental Medicine”

Phellodendri Cortex Extract may help treat enlarged prostate.

research Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm

4 citations , October 2018 in “Asia-Pacific Journal of Clinical Oncology”

CDK4/6 inhibitors have improved treatment outcomes for certain advanced breast cancer patients.

Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

research Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia

23 citations , January 2021 in “Biomedicine & Pharmacotherapy”

DHT stops hair regrowth in mice, similar to human hair loss.

research FRI220 Primary Bilateral Macronodular Adrenal Hyperplasia: A Rare Cause Of Cushing Syndrome

October 2023 in “Journal of the Endocrine Society”

A rare case of Cushing syndrome was successfully treated with one-sided adrenal gland removal, suggesting personalized treatment is important.

research Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus

19 citations , July 2019 in “Journal of Endocrinology”

GTx-024 and Danazol affect the uterus like DHT, while GTx-007 has little impact.

research Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist

9 citations , April 2021 in “Expert opinion on pharmacotherapy”

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

Response to Baricitinib in the Treatment of Patients with Early and Late Onset Alopecia Areata in the Phase 2 Portion of BRAVE-AA1 Randomized Controlled Trial

research 27604 Response to baricitinib in the treatment of patients with early and late onset alopecia areata in the phase 2 portion of BRAVE-AA1 randomized controlled trial

1 citations , August 2021 in “Journal of The American Academy of Dermatology”

Baricitinib was effective in treating both early and late onset alopecia areata.

research The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles.

3 citations , December 2000 in “PubMed”

CS-891 may effectively treat hair loss by blocking enzymes in hair follicles.

Successful Treatment with Upadacitinib in Concurrent Atopic Dermatitis, Crohn's Disease, Alopecia Areata, and Eosinophilic Gastropathy in a Pediatric Patient

research Successful treatment with upadacitinib in concurrent atopic dermatitis, Crohn’s disease, alopecia areata, and eosinophilic gastropathy in a pediatric patient

January 2026 in “Dermatology Reports”

Upadacitinib improved symptoms and hair regrowth in a teen with multiple autoimmune conditions.

research 7288 A Preclinical Mouse Model of Gender-Affirming Hormone Therapy: Metabolic and Behavioral Outcomes

October 2024 in “Journal of the Endocrine Society”

Gender-affirming hormone therapy affects metabolism differently based on treatment type.

research LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent

6 citations , October 2021 in “Brain Sciences”

Dutasteride may help reduce brain inflammation and improve cognition.

research Role of Neurosteroidogenic Pathways in the Antiseizure Activity of Midazolam in the 6‐Hz and Kindling Models of Epilepsy

April 2015 in “The FASEB Journal”

Midazolam's antiseizure effects are mainly due to synaptic GABA-A receptors, not neurosteroids or extrasynaptic receptors.

Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata Over 52 Weeks in Phase III Trials

research Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata over 52 Weeks of Continuous Therapy in Two Phase III Trials (BRAVE-AA1 and BRAVE-AA2)

20 citations , March 2023 in “American Journal of Clinical Dermatology”

Baricitinib improved severe hair loss in adults over 52 weeks and was safe to use.

research β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model

14 citations , July 2017 in “Fitoterapia”

Oleanolic acid promotes hair growth by increasing cell proliferation through the Wnt/β-catenin pathway.

research Network Pharmacology Reveals Curcuma aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia

July 2024 in “Biology”

Curcuma aeruginosa Roxb. may help treat hair loss by affecting specific biological pathways.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

63 citations , May 2011 in “Clinical cancer research”

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

research Changes in expression of the δ subunit of the GABA_Areceptor and in receptor function induced by progesterone exposure and withdrawal

25 citations , July 2006 in “Journal of Neurochemistry”

Progesterone affects GABA_A receptor function by altering δ subunit levels.

research Reversal of alopecia areata, osteoporosis follow treatment with activation of Tgr5 in mice

14 citations , July 2021 in “Bioscience Reports”

Activating Tgr5 may help treat hair loss and bone loss.

research 5α-Reduced glucocorticoids: a story of natural selection

46 citations , September 2011 in “Journal of Endocrinology”

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

research Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors

14 citations , February 2018 in “Psychoneuroendocrinology”

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

research Successful treatment of severe diffuse alopecia areata with abrocitinib

April 2025 in “Anais Brasileiros de Dermatologia”

Abrocitinib effectively treats severe alopecia areata with significant improvement and no side effects.

research Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice

4 citations , January 2025 in “International Journal of Molecular Sciences”

Progesterone reduces anxiety and depression in female mice by increasing BDNF in the brain, needing 5α-reduction and estradiol.

research Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

164 citations , December 1984 in “Proceedings of the National Academy of Sciences”

TCDD reduces EGF receptor activity and causes various developmental changes in animals.

research Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

25 citations , January 2024 in “Journal of Lipids”

Cubosomes improve drug delivery for skin and eye diseases by enhancing adhesion, retention, and release.

research Advances in the understanding of androgen receptor structure and function and in the development of next-generation AR-targeted therapeutics

6 citations , August 2024 in “Steroids”

research β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid

42 citations , June 2019 in “Aging”

3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations , August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

research The Effect of Perinatal Blockade of Androgen Receptors on the Expression of Hypothalamic Estrogen Receptor‐a and Sexual Motivation in Male Rats

April 2016 in “The FASEB Journal”

Blocking androgen receptors early in life increases estrogen levels and reduces sexual motivation in male rats.

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