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GlossaryCB1 receptor

protein in the brain that interacts with cannabinoids

The CB1 receptor, also known as the Cannabinoid receptor type 1, is a protein found primarily in the brain and central nervous system. It plays a crucial role in regulating various physiological processes, including mood, appetite, pain sensation, and memory, by interacting with endocannabinoids and cannabinoids like THC from cannabis.

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Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

research Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle

14 citations , February 2021 in “Experimental Dermatology”

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

research Cannabinoids and Their Receptors in Skin Diseases

1 citations , November 2023 in “International journal of molecular sciences”

Cannabinoids might help treat skin problems but more research is needed to be sure.

research 438 Laminin-511 is a new player in the development of psoriasis and controlled via cannabinoid receptor type 1

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Laminin-511 is involved in psoriasis development and can be regulated by cannabinoid receptor type 1.

research 1348 Involvement of mast cells and CB1 in the pathogenesis of IgA vasculitis

April 2023 in “Journal of Investigative Dermatology”

Mast cells and the CB1 receptor may be key in causing IgA vasculitis.

research A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytesin vitroandin situ

66 citations , February 2013 in “PeerJ”

Activating cannabinoid receptor 1 reduces certain keratin levels, potentially aiding psoriasis treatment.

research Peer Review #2 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

February 2013

Activating CB1 can reduce keratin levels, potentially helping manage psoriasis and aid wound healing.

research Peer Review #1 of "A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (v0.1)"

February 2013

Activating cannabinoid receptor 1 may help manage psoriasis by reducing certain keratins.

17β-Estradiol May Control Human Hair Follicle Growth Also via Up-Regulating the Expression of Cannabinoid Receptor Type 1

research 1370 17β-estradiol may control human HF growth also via up-regulating the expression of cannabinoid receptor type1 expression

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

142 citations , March 2019 in “Molecules/Molecules online/Molecules annual”

Cannabinoids may help treat various skin conditions.

research Endocannabinoids limit excessive mast cell maturation and activation in human skin

124 citations , January 2012 in “Journal of Allergy and Clinical Immunology”

Endocannabinoids help control mast cell activity in human skin.

research Targeting Cutaneous Cannabinoid Signaling in Inflammation - A “High”-way to Heal?

28 citations , January 2017 in “EBioMedicine”

Enhancing cannabinoid signaling may help treat skin inflammation.

research Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases?

26 citations , May 2014 in “BioEssays”

Using neurohormones to control keratin can lead to new skin disease treatments.

research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

3 citations , December 2022 in “Cells”

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.

research Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System

2 citations , January 2020 in “Evidence-based Complementary and Alternative Medicine”

Hataedock treatment improved skin health and reduced atopic dermatitis symptoms by enhancing the skin barrier and reducing inflammation.

research Case Study of Hair Regrowth with Topical Cannabidiol (CBD)

1 citations , July 2021 in “Hair transplant forum international”

Daily use of CBD-rich hemp oil significantly increased hair growth in people with hair loss.

research 477 How Cannabidiol Supports Hair Growth: From Epigenetics to the Scalp Microbiome

November 2025 in “Journal of Investigative Dermatology”

CBD can help hair grow by supporting scalp health and reducing inflammation.

research Neuroendocrine Controls of Keratin Expression in Human Skin

December 2018 in “IntechOpen eBooks”

Neurohormones help control skin health and could treat skin disorders.

research Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation

8 citations , June 2024 in “Pharmaceutics”

PEA-ENL improves skin delivery and reduces inflammation without side effects.

research LPA3, a unique G protein-coupled receptor for lysophosphatidic acid

31 citations , October 2010 in “Progress in lipid research”

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

research Non-Edg family LPA receptors: the cutting edge of LPA research

68 citations , July 2011 in “Journal of Biochemistry/The journal of biochemistry”

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

research The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders

75 citations , August 2018 in “Biochemical pharmacology”

Targeting the skin's endocannabinoid system could help treat skin disorders.

research Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner

28 citations , May 2015 in “Addiction Biology”

Prenatal stress changes how male and female rats enjoy rewards differently, linked to sex hormones.

research A Summary of Pre-Clinical and Clinical Evidence for Cannabinoid Hair Follicle Effects

January 2022 in “Clinical dermatology open access journal”

Certain cannabinoids may help increase hair growth and could be useful for treating hair loss.

research Beyond acne: Current aspects of sebaceous gland biology and function

97 citations , September 2016 in “Reviews in Endocrine and Metabolic Disorders”

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

research Stem Cells and their Niches

1 citations , January 2013 in “Journal of Investigative Dermatology”

The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.

research Beta-caryophyllene enhances wound healing through multiple routes

67 citations , December 2019 in “PloS one”

Beta-caryophyllene helps improve wound healing in mice, especially in females.

research Beta-caryophyllene enhances wound healing through multiple routes

3 citations , April 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

Beta-caryophyllene, found in essential oils, helps wounds heal better in multiple ways.

research Hormones and the pilosebaceous unit

97 citations , March 2009 in “Dermato-endocrinology”

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

research Scientific Evidence for the Cosmetic Skin and Hair Benefits of Hemp-derived Cannabinoids: A Review

January 2024 in “Clinical dermatology open access journal”

Hemp-derived cannabinoids can benefit skin and hair without causing a high.

research Novel lysophosphoplipid receptors: their structure and function

158 citations , June 2014 in “Journal of Lipid Research”

Lysophospholipids can act as anti-inflammatory agents through specific receptors, but more research is needed.