Search

for
Search:

Sort by

Research

240-270 / 1000+ results

research Ginkgolide B and bilobalide promote the growth and increase β‐catenin expression in hair follicle dermal papilla cells of American minks

12 citations , September 2019 in “BioFactors”

Ginkgolide B and bilobalide help mink hair grow by making skin cells healthier and boosting a key growth protein.

research Expression, characterization, and structural analysis of human liver delta4-3-ketosteroid 5beta-reductase (AKR1D1) and its disease-related mutant P133R

January 2009 in “ScholarlyCommons (University of Pennsylvania)”

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

research CtBP1 Overexpression in Keratinocytes Perturbs Skin Homeostasis

9 citations , November 2013 in “Journal of Investigative Dermatology”

Overexpressing CtBP1 in skin cells causes skin and hair problems.

research Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers

11 citations , November 2021 in “JBMR plus”

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

research Targeting cardiac hypertrophy through a nuclear co‐repressor

3 citations , October 2019 in “EMBO molecular medicine”

Targeting NCoR1 can help treat heart enlargement and dysfunction.

research Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.

164 citations , December 1984 in “Proceedings of the National Academy of Sciences”

TCDD reduces EGF receptor activity and causes various developmental changes in animals.

Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals

research Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals

25 citations , November 2013 in “PLoS ONE”

Estrogen and androgen signals control synaptic changes in rat brains.

research Allosteric interactions prime androgen receptor dimerization and activation

1 citations , February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.

research Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted ^99mTc-Radioimaging Agents

148 citations , April 2009 in “Molecular Pharmaceutics”

Researchers developed promising agents for prostate cancer imaging, with the best one showing high potential for clinical use.

research Abstract 1026: A non-apoptotic function for Mcl-1 as an activator of canonical Wnt signaling in keratinocytes

April 2010 in “Cancer Research”

Mcl-1 can activate Wnt signaling in skin cells, promoting growth and possibly cancer.

research Lrig1 Expression in Human Sebaceous Gland Tumors

3 citations , May 2016 in “Dermatopathology”

Lrig1 could be a marker for advanced sebaceous carcinoma.

research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

3 citations , October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

Multicentric Parallel Phase II Trial of the Polo-Like Kinase 1 Inhibitor BI 2536 in Patients With Advanced Head and Neck Cancer, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, and Melanoma. The First Protocol of the European Organization for Research and Treatment of Cancer Network of Core Institutes

research Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

93 citations , May 2010 in “European Journal of Cancer”

BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.

research Androgen Receptor Ligands: Agonists and Antagonists

2 citations , November 2017 in “Elsevier eBooks”

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

research BindingDB Entry 50021519: Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

January 2025

research Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

25 citations , January 2024 in “Journal of Lipids”

Cubosomes improve drug delivery for skin and eye diseases by enhancing adhesion, retention, and release.

Ca2+ Mediated Protein Citrullination Regulates Proliferation in the Regenerating and Malignant CNS

research Ca ²⁺ -mediated protein citrullination regulates proliferation in the regenerating and malignant CNS

January 2026

Ca²⁺-mediated protein citrullination controls cell growth in the CNS and may help treat brain tumors.

research New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway

January 2022 in “Current Enzyme Inhibition”

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

research Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism

19 citations , December 2016 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Certain drugs increase calcium levels in cancer cells by triggering internal calcium release.

research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

18 citations , December 2005 in “Journal of Medicinal Chemistry”

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

research Dual role of laminin‑511 in regulating melanocyte migration and differentiation

17 citations , September 2018 in “Matrix Biology”

Laminin-511 is essential for proper melanocyte movement and development in mice.

research GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects

59 citations , August 2021 in “Frontiers in Endocrinology”

GLP-1 receptor agonists, like Dulaglutide, Liraglutide, and Semaglutide, have potential benefits beyond the pancreas, including neuroprotection, pain suppression, cardiovascular protection, obesity management, and cancer treatment, but there are concerns about pancreatitis and pancreatic cancer risks.