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Large-Scale Skin scRNA-Seq Profiling Highlights Distinct Body Site-Specific Ligand-Receptor Interactions and Pathways in Keratinocytes

research LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes

August 2023 in “Journal of Investigative Dermatology”

Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.

research iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata

27 citations , April 2018 in “Journal of autoimmunity”

iNKT cells can help prevent and treat alopecia areata by promoting hair regrowth.

research Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata

48 citations , September 2011 in “British Journal of Dermatology”

Epigenetic changes in blood cells may contribute to alopecia areata.

research Safe Selection of Genetically Manipulated Human Primary Keratinocytes with Very High Growth Potential Using CD24

25 citations , August 2007 in “Molecular Therapy”

Researchers found a safe and effective way to pick genetically modified skin cells with high growth potential using CD24.

research Intercellular Adhesion Molecule-1 and Hair Follicle Regression

29 citations , April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

ICAM-1 helps regulate hair growth cycles and skin remodeling.

research DNA methylation of microRNA-365-1 induces apoptosis of hair follicle stem cells by targeting DAP3

7 citations , March 2024 in “Non-coding RNA Research”

This study investigates the role of DNA methylation in chemotherapeutic alopecia using a mouse model induced by cyclophosphamide (CTX). It was found that DNA methylation of microRNA-365-1 (miR-365-1) plays a significant role in the apoptosis of hair follicle stem cells by targeting the DAP3 gene. The study demonstrated that hypermethylation of miR-365-1 leads to increased apoptosis in hair follicle stem cells, as evidenced by reduced expression of hair follicle stem cell markers and increased apoptotic markers. Overexpression of miR-365-1 reduced apoptosis, but this effect was partially reversed by overexpressing DAP3. These findings highlight the importance of miR-365-1 methylation in the regulation of hair follicle stem cell apoptosis during chemotherapeutic alopecia.

research Conversion of C57Bl/6 mice from a tumor promotion-resistant to a -sensitive phenotype by enhanced ornithine decarboxylase expression

31 citations , September 1999 in “Molecular Carcinogenesis”

Increased ornithine decarboxylase makes normally tumor-resistant mice more sensitive to tumors.

research RETRACTED: Causal role of immune cells in alopecia areata: A two‐sample Mendelian randomization study

14 citations , January 2024 in “Skin Research and Technology”

The study suggested certain immune cells might cause alopecia areata, but it was retracted.

research 3D spheroid culture synchronizes heterogeneous MSCs into an immunomodulatory phenotype with enhanced anti-inflammatory effects

13 citations , August 2024 in “iScience”

3D spheroid culture makes stem cells better at reducing inflammation.

research A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

67 citations , November 2019 in “Nature Communications”

Oncogenic melanocyte stem cells can develop into melanoma similar to human cases.

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