research IMMUNE-RELATED SKIN TOXICITIES TO CHECKPOINT INHIBITORS THERAPY
Checkpoint inhibitor therapy can cause skin issues, from mild rashes to severe reactions.
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research 785 Single-cell transcriptomic profile of EGFR-deficient epidermal compartments during folliculitis
EGFR deficiency causes significant changes in skin cells and hair follicles.
research 0935 Unravelling the role of JAK3/TEC kinase signalling with ritlecitinib in alopecia areata lesional skin and alopecia areata-induced human hair follicles ex vivo
Ritlecitinib reduces alopecia areata symptoms by blocking JAK3/TEC signaling and T-cell activity.
research Where is the data? Delayed and chronic irAE surveillance and management after cessation of ICIs: expert insights from SITC on survivorship care and the need for long-term data
Long-term data and a team approach are needed to manage chronic side effects from cancer treatments.
research Decision letter: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium
Skin cells can naturally limit the growth of cancerous changes by balancing cell renewal and differentiation.
research Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing
A humanized CXCL12 antibody may delay and treat alopecia areata by altering the immune response.
research Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis
Key genes linked to immune response are highly active in lupus-affected hair follicles.
research Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate
TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.
research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.
research SnapshotDx Quiz: September 2018
Tofacitinib may help regrow hair in alopecia areata patients.
research Dermatologic Changes Associated With Interleukin 2 Administration
IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.
research P0881 Effectiveness and Safety of Tofacitinib in Biologic-Naïve Elderly Patients with Ulcerative Colitis
Tofacitinib is effective and safe for elderly patients with ulcerative colitis.
research Demodex folliculitis
Demodex folliculitis can occur in HIV patients on HAART, and treatment may involve topical creams or medication changes.
research Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity
The skin can independently form immune responses through special structures, offering new ways to treat skin diseases.
research Thymosin β4 Identified by Transcriptomic Analysis from HF Anagen to Telogen Promotes Proliferation of SHF-DPCs in Albas Cashmere Goat
Thymosin β4 helps increase hair growth in Cashmere goats.
research TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis
research Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
Activated LEF/TCF complexes are crucial for hair development and cycling.
research Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis
iNKT cells help develop and maintain healthy skin in young mice.
research Global trends in tertiary lymphoid structures: a bibliometric analysis from 2014 to 2023
Tertiary lymphoid structures are important in immunotherapy and need more research.
research Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing its Impact on T Regulatory Cell and NK Cell Populations
The study's results on the effectiveness of low-dose IL-2 for alopecia areata and its impact on immune cells were not provided.
research Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments
Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.
research Multiple potential roles of thymosin β4 in the growth and development of hair follicles
Thymosin β4 may boost hair growth by aiding stem cell movement and blood vessel formation.
research Differentiation of CD34+ Human Hair Follicle Stem Cells into Functional Melanocytes
CD34+ hair follicle stem cells can become melanin-producing cells for treating skin conditions.
research Concentrated growth factor therapy as cosmetic treatment in discoid lupus erythematosus
CGF therapy may help hair regrowth and improve scars in DLE patients.
research Clinical observation and evaluation of CGF in the treatment of androgenic alopecia
CGF treatment effectively and safely improves hair loss in androgenic alopecia patients.
research Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration
research 320 An open label clinical trial of Abatacept (CTLA4-Ig) for alopecia areata
Abatacept may help some people with alopecia areata regrow hair.
research Comparison of the Treatment Outcome of Oral Tofacitinib with Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study
Tofacitinib works better and is more tolerable for severe alopecia than conventional treatments and DPCP immunotherapy.
research LAM/TSC Cell Migration to Uterus in an Experimental Model of Lymphangioleiomyomatosis. Regulation by Anti-Epidermal Growth Factor Receptor Antibody and Rapamycin
Rapamycin and anti-EGFR antibody reduce LAM/TSC cell migration and blood vessel growth in the uterus.
research Visualization of individual cell division history in complex tissues
The tool iCOUNT helps understand how stem cells divide and affect tissue development and repair.