research Quantification of mast cells in central centrifugal cicatricial alopecia
Mast cells may significantly contribute to central centrifugal cicatricial alopecia.
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research Transgenic mice overexpressing CD109 in the epidermis display decreased inflammation and granulation tissue and improved collagen architecture during wound healing
Mice genetically modified to produce more CD109 in their skin had less inflammation and better healing with less scarring.
research CD8 T cells require IFNg to induce disease in a murine model of Alopecia Areata 2310132
CD8 T cells need interferon gamma to cause Alopecia Areata.
research 7DHC and BM15766 treated mice (C57BL/6; n = 5) failed to regrow the hairs.
The treatments stopped hair regrowth in mice.
research Risk and Benefit of CD133 + Progenitors
CD133+ progenitor cells have therapeutic potential for diabetic ulcers and heart attack recovery, with manageable risks.
research Stepwise acquisition of unique epigenetic signatures during differentiation of tissue Treg cells
Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.
research 0073 Single-cell analysis reveals divergent dendritic cell-fibroblast signaling in lesional versus non-lesional cutaneous lupus
research IMMUNE-DRIVEN ACTIVATION OF HAIR FOLLICLE STEM CELLS AS A TRANSLATIONAL MODEL FOR FUTURE CELL-BASED THERAPY DEVELOPMENT
Immune activation of hair follicle stem cells can help develop new hair regeneration therapies.
research CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice
CD34 is crucial for skin tumor development in mice.
research Skin Wound Healing
Using a specific binding agent and low doses of FK506 can stimulate stem cells, speeding up skin healing by 25% and improving skin quality in rats and mice.
research CD4+ Treg expansion arrests disease progression in a pre-clinical model of alopecia areata
Expanding CD4+ Tregs can stop hair loss in alopecia areata.
research Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells
Human thymus has stem cells that can self-renew and maintain their identity.
research Location and phenotype of human adult keratinocyte stem cells of the skin
Stem cells are in deep skin layers, while differentiating cells are in shallow layers.
research A novel monoclonal antibody to the outer root sheath cells
The new antibody, TYHF-1, specifically targets certain hair-related structures.
research 686 UVB irradiation with anti-CD154 antibody prolonged the survival of hair follicle allografts in humanized mice
Combining UVB irradiation and anti-CD154 antibody improves hair follicle transplant survival.
research Mechanical stimuli-induced CCL2 restores adult mouse cells to regenerate hair follicles
Mechanical stimuli and CCL2 can help regenerate hair follicles in adult mice.
research Comparison of CD146 +/− mesenchymal stem cells in improving premature ovarian failure
CD146 + mesenchymal stem cells are more effective for treating premature ovarian failure.
research The function of BST2 in γδ T Cells, CD8 T Cells, and macrophages in alopecia areata pathogenesis 4231
BST2 is highly expressed in certain immune cells in alopecia areata, suggesting a role in the disease.
research Commensal microbe regulation of skin cells in disease
research Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin
Hair follicles help attract immune cells to the skin during stress.
research Author response: IL18 signaling promotes homing of mature Tregs into the thymus
IL-18 signaling helps mature Tregs move into the thymus.
research Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice
Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.
research Human dermal Vδ1 + T-cells recognize “stressed” HFs and may induce alopecia areata
Certain immune cells may cause hair loss by reacting to stressed hair follicles.
research MmuPV1 infection and tumor development of T cell-deficient mice is prevented by passively transferred hyperimmune sera from normal congenic mice immunized with MmuPV1 virus-like particles (VLPs)
Giving immune serum from vaccinated mice to mice without T cells prevents infection and tumor growth.
research Exploring the Relationship Between Immune Cells and Non-Scarring Hair Loss: A Mendelian Randomization Study
Certain immune cells are linked to non-scarring hair loss, suggesting potential for immune-targeted treatments.
research Anti‐keratin Monoclonal Antibody against Basal Cell Epithelioma Keratin: BKN‐1
BKN-1 antibody targets specific keratin in basal cell epithelioma and normal skin basal cells.
research Distribution of major histocompatibility antigens in normal skin
Major histocompatibility antigens are found in specific skin cells and structures, but not in sweat glands.
research Immunomodulators in the treatment of cutaneous lymphoma
Immunomodulatory therapies are effective for treating cutaneous lymphoma, particularly in early stages.
research CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment
CD80 on skin stem cells helps expand Treg cells to aid wound healing.
research Prophylactic Amotosalen-Treated Donor T-Cells Prevent Late CMV Infection in Allogeneic Bone Marrow Transplantation.
Amotosalen-treated donor T-cells can prevent late CMV infection after bone marrow transplants.