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research Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

12 citations , January 1987 in “Carcinogenesis”

TCDD changes skin cell growth and keratin production in mice.

The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

146 citations , May 2002 in “The American journal of pathology”

Cathepsin L is essential for normal hair growth and development.

research CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance

11 citations , September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific group of skin stem cells was found to help maintain hair follicle cells.

research Ichthyosis with confetti: clinics, molecular genetics and management

36 citations , September 2015 in “Orphanet Journal of Rare Diseases”

Revertant cell therapy could be a future treatment for Ichthyosis with confetti.

research Identification of the C-terminal tail domain of AHF/trichohyalin as the critical site for modulation of the keratin filamentous meshwork in the keratinocyte

12 citations , December 2011 in “Journal of Dermatological Science”

The C-terminal tail of AHF/trichohyalin is essential for organizing keratin filaments in keratinocytes.

Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research 1367 Inhibition of the mitochondrial pyruvate carrier promotes ATF4–dependent stress responsive metabolic rewiring and cell cycle arrest in the human hair follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

research The incidental pore: Ca_V1.2 and stem cell activation in quiescent hair follicles

3 citations , June 2013 in “Genes & development”

CaV1.2 helps activate hair follicle stem cells without calcium flux.

research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

27 citations , July 2017 in “Scientific Reports”

N-WASP is essential for healthy skin and preventing inflammation.

research A Mosaic Hotspot PLCD1 Variant, Detectable in Blood‐Derived DNA, Associated With Nevus Trichilemmocysticus

March 2025 in “American Journal of Medical Genetics Part A”

A rare genetic variant linked to skin cysts was found in blood DNA, suggesting its role in cyst formation.

research Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

665 citations , April 2016 in “Nature communications”

Blocking specific proteins can help remove aging cells and might treat age-related diseases and promote hair growth.

research Basonuclin as a cell marker in the formation and cycling of the murine hair follicle

January 1998 in “Differentiation”

Basonuclin is crucial for hair follicle development and cycling in mice.

research TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population

9 citations , January 2015 in “Medical hypotheses”

TCDD disrupts skin stem cells, causing skin issues like chloracne.

research ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway

5 citations , July 2024 in “Journal of Microbiology and Biotechnology”

ICP5249 helps hair grow by activating a specific cell pathway.

research Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer

December 2024 in “European journal of medical research”

research Heterogeneity of ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors

37 citations , January 1986 in “Carcinogenesis”

ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.

research Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

990 citations , October 1999 in “Development”

Activated LEF/TCF complexes are crucial for hair development and cycling.

research Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation

5 citations , January 2024 in “JID Innovations”

CCCA involves immune response and metabolism issues, suggesting new treatment options.

Differential Distribution of the Epigenetic Marker 5-Hydroxymethylcytosine in Hair Follicle Stem Cells During Bulge Activation

research Differential distribution of the epigenetic marker 5‐hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation

4 citations , February 2019 in “Journal of Cutaneous Pathology”

The marker 5-hmC changes in hair follicle stem cells when they start to grow.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

3 citations , January 2023 in “Science advances”

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

research Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C

26 citations , May 2007 in “Differentiation”

Foxn1 helps skin cells mature by controlling a specific protein's activity.

research Promotion of mouse ameloblast proliferation by Lgr5 mediated integrin signaling

7 citations , April 2013 in “Journal of Cellular Biochemistry”

CD61 is important for mouse tooth cell growth and works through Lgr5.

research Hoxc13 and the development of hair follicle

10 citations , August 2010 in “Hereditas (Beijing)”

Hoxc13 is essential for hair growth and follicle development.

research Pattern of expression of c-Myc, Max and Bin1 in human anagen hair follicles

11 citations , June 2001 in “British Journal of Dermatology”

c-Myc, Max, and Bin1 help hair follicle cells mature and die.

research Reversible Activation of c-Myc in Skin

467 citations , May 1999 in “Molecular Cell”

Activating c-Myc in skin causes rapid cell growth and changes, but these effects are reversible.

research Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion

April 2012 in “Cancer research”

Blocking mTORC1 may help prevent skin cancer by stopping the growth of certain skin stem cells.

research BMP4 and nuclear laminC orchestrate a expression of AHF/Trichohyalin molecule, a key modulator of keratin intermediate filaments in the hair follicle

January 2007

research 1393 Lower proximal cup cells but not bulge stem cells regenerate hair follicles after chemotherapy injury

1 citations , April 2018 in “Journal of Investigative Dermatology”

Lower proximal cup cells, not bulge stem cells, regenerate hair follicles after chemotherapy.

research Data from Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

March 2023

Loss of the p53 gene alone causes tumors, and losing both p53 and Rb genes speeds up aggressive skin cancer.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

Activin B can boost hair growth by promoting cell proliferation and cell cycle progression.

research CD98hc (SLC3A2) regulation of skin homeostasis wanes with age

35 citations , January 2013 in “The Journal of experimental medicine/The journal of experimental medicine”

CD98hc's role in skin health decreases with age.

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