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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Targeting multiple pathways may improve treatments for androgenetic alopecia.

Key genes and pathways, including Wnt, NF-Kappa, and JAK-STAT, are crucial for starting Pashmina fiber growth in goats.

Cholecystokinin may help reduce skin inflammation in psoriasis.

Potential new drugs for treating PCOS were identified.

15-lipoxygenase helps keep skin healthy by reducing inflammation.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Hormones, genes, and oxidative stress interact to cause hirsutism and PCOS.

Higher estrone-to-estradiol ratios are linked to worse glucose metabolism and insulin resistance in women with PCOS.

Dietary L-serine supplementation can reduce symptoms of HSAN1 by lowering harmful 1-deoxySL levels.

Lower SHBG levels may increase the risk of PCOS.

Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.

High homocysteine levels in lupus may increase inflammation and cardiovascular risk.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Lipids may help treat hair loss by promoting hair growth through the HIF-1 pathway.

Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.

The study identified a key protein involved in producing underarm odor and found ways to inhibit it.

A new method accurately measures nine neuroactive steroids in small blood samples, helping to study brain diseases.

Higher activity in lichen planopilaris is linked to certain immune and tissue genes.

Blocking the HEDGEHOG-GLI1 pathway can reduce keloid growth and may be a potential treatment.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Women with PCOS often have hirsutism and skin changes, which indicate a need for metabolic health checks.

Adipose tissue changes in obesity can trigger stress in fat cells.

Over 30 potential cancer prevention treatments are being tested, with some showing promise in early research.

The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.