January 2025 in “Seizure” Dual anti-seizure medications, especially valproic acid with lamotrigine, often cause more side effects like hair loss and memory issues.
2 citations
,
April 2017 in “Asian Journal of Psychiatry” Valproic acid can cause hair loss when taken orally but may promote hair growth when applied topically.
169 citations
,
August 1981 in “BMJ” Sodium valproate improved epilepsy control but often caused weight gain in children.
May 2021 in “American journal of medical sciences and medicine” Sodium valproate caused vomiting in 20% of children under 2 years old, with other side effects like hair loss and loss of appetite also noted.
3 citations
,
October 1976 in “BMJ” Sodium valproate can cause low platelets and hair loss.
6 citations
,
June 2013 in “Toxicological Research” Topical Valproate is safe for human skin and unlikely to cause irritation.
6 citations
,
April 2013 in “International Journal of Dermatology” Valproic acid helped hair growth in alopecia patient; more research needed.
1 citations
,
September 2007 in “European journal of paediatric neurology” Low dose valproic acid treatment caused hair loss in a young patient.
Convulsofin effectively treats primary epilepsy but has some side effects.
47 citations
,
March 2019 in “Journal of immunology research” Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.
July 2020 in “Scholars journal of applied medical sciences” Sodium valproate caused vomiting, hair loss, loss of appetite, abdominal pain, weight gain, and anemia in young children with epilepsy.
3 citations
,
August 2023 in “The Journal of Pediatrics” Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.
August 2018 in “Dermatologic Surgery”
February 2025 in “International Journal of Morphology” Vitamin E can reduce the negative effects of valproic acid on hair and skin development.
7 citations
,
March 2018 in “Psychiatry and Clinical Psychopharmacology” Valproate can cause brain swelling with high ammonia levels, possibly underreported, especially in psychiatric patients.
16 citations
,
February 2009 in “Clinical neurology and neurosurgery” Switching to extended-release divalproex sodium improved patient-reported tremor but did not change seizure frequency or most side effects.
2 citations
,
September 2014 in “International Journal of Dermatology” Sodium valproate can worsen psoriasis-like skin conditions.
18 citations
,
January 2009 in “Acta neurologica Scandinavica” Long-term sodium valproate treatment for epilepsy generally caused mild and temporary side effects.
9 citations
,
January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology” Higher doses of the medication valproate can cause hair loss, which may stop when the dose is lowered or the medication is stopped.
1 citations
,
April 2002 in “PubMed” Anti-epileptic drugs may cause visual and hair side effects due to enzyme inhibition, especially in genetically predisposed individuals.
June 2021 in “Clinical neuropsychopharmacology and therapeutics” Valproic acid can cause hair color change in older men.
29 citations
,
October 2009 in “Pharmacology Biochemistry and Behavior”
21 citations
,
June 2011 in “Journal of child neurology” Valproic acid and carbamazepine do not change biotin or biotinidase levels but may lower zinc levels, still within normal range.
11 citations
,
January 2018 in “International journal of trichology” Valproate can cause hair loss and changes in hair appearance, but may help regrow hair when applied topically.
5 citations
,
August 2017 in “The Journal of Clinical Psychiatry” Biotin may effectively treat hair loss caused by valproate medication.
Sodium valproate caused hair loss and curly hair in 3.5% of patients.
11 citations
,
January 2020 in “Engineered science” 2 citations
,
November 2011 in “Current psychiatry” 59 citations
,
October 1976 in “BMJ” Sodium valproate can cause low platelet count.
July 2014 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Applying valproic acid on the scalp increased hair growth in men with hair loss.