2 citations
,
June 1986 in “Journal of Clinical Pharmacy and Therapeutics” Metal binding to sodium valproate may be linked to hair loss in epilepsy patients.
June 2023 in “International Journal of Pharmaceuticals Nutraceuticals and Cosmetic Science” New information shows Valproate may protect the brain and reduce breathing failure risk but can cause liver damage and other side effects, with genetics affecting dosage needs.
13 citations
,
April 2019 in “Seizure” Valproic acid increases the risk of hair loss more than other drugs, especially in migraine patients, and lamotrigine may be a safer alternative.
1 citations
,
December 2024 in “ACS Biomaterials Science & Engineering” 12 citations
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May 2005 in “Journal of the American Geriatrics Society” Stopping valproate and using lactulose can quickly treat valproate-induced hyperammonemia.
November 2022 in “Indian Journal of Dermatology/Indian journal of dermatology” Valproic acid can cause dark lines on nails.
2 citations
,
April 2023 in “Curēus” Valproic acid can cause muscle damage and liver issues, which improve after stopping the drug.
20 citations
,
August 1981 in “Developmental Medicine & Child Neurology” 13 citations
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June 1981 in “Developmental Medicine & Child Neurology”
1 citations
,
October 2023 in “Journal of clinical psychopharmacology” Divalproex sodium can cause pleural effusion, which stops when the drug is discontinued.
5 citations
,
November 2012 in “Journal of Clinical Psychopharmacology” Valproic acid and isoniazid can interact, causing toxicity, so careful monitoring is needed.
29 citations
,
March 1987 in “Therapeutic Drug Monitoring” Combining sodium valproate with other epilepsy drugs increases ammonia levels and side effects.
July 2008 in “European Journal of Cancer Supplements” 4 citations
,
October 2015 in “JAAD Case Reports” Surgical grafting may fix nail issues caused by valproic acid.
January 2016 in “International journal of clinical pediatrics” Valproic acid may cause temporary hair changes like loss or thinning in children.
April 2025 in “Suez Canal University Medical Journal” Valproic acid can rarely cause fluid buildup around the lungs and heart.
17 citations
,
January 2013 in “Indian Journal of Pharmacology” High levels of the seizure medication sodium valproate can cause hair loss.
January 2025 in “Dusunen Adam The Journal of Psychiatry and Neurological Sciences”
Topical valproate can effectively promote hair growth.
April 2024 in “Lečaŝij vrač” Valproic acid can cause low platelet counts, especially at high doses or in elderly patients.
16 citations
,
May 2009 in “Journal of child neurology” Valproic acid does not change biotinidase enzyme activity in children's blood.
January 2024 in “Specialty journal of Pharmacognosy Phytochemistry and Biotechnology” Genetic factors may influence how well valproic acid works and its side effects in epilepsy treatment.
64 citations
,
October 2017 in “Colloids and surfaces. B, Biointerfaces” Chitosan-coated nanoparticles can effectively deliver positively charged drugs through the skin using iontophoresis.
68 citations
,
March 2018 in “Biomaterials” Tiny needles with valproic acid can effectively regrow hair.
1 citations
,
September 2007 in “Neuromuscular disorders” The treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may improve muscle strength in children with SMA without significant side effects.
73 citations
,
October 2001 in “Epilepsia” Children taking higher doses of valproic acid had lower biotinidase activity, which may lead to biotin deficiency, but biotin supplements could help.
4 citations
,
January 2019 in “PubMed” Low dose valproate in epileptic children mainly causes weight gain and other non-life-threatening side effects.
March 2025 in “Biomedical & Pharmacology Journal” Valproic acid is effective but often causes side effects like weight gain and hair loss, so personalized treatment is needed.
35 citations
,
August 2004 in “Epilepsy & behavior” Extended-release divalproex is better tolerated and more effective for seizures and psychiatric symptoms than delayed-release divalproex, but doesn't reduce hair loss.
13 citations
,
January 2007 in “Epilepsia” Valproic acid can cause reversible hair curling and persistent hair thinning.