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$Mitoxantrone, Etoposide, and Prednisolone: A Novel Combination in the Treatment of Relapsed and Refractory Lymphoma$

research Mitoxantrone, Etoposide and Prednisolone—a Novel Combination in The Treatment of Relapsed and Refractory Lymphoma

2 citations , January 1990 in “Leukemia & Lymphoma”

The combination of mitoxantrone, etoposide, and prednisolone is effective for treating relapsed lymphoma with manageable side effects.

Inhibition of the Pro-Oxidant Effects of Benoxaprofen on Polymorphonuclear Leucocytes by Retinol Acetate In Vitro

research Inhibition of the pro-oxidant effects of benoxaprofen on poiymorpbonuclear leucocytes by retinol acetate in vitro

2 citations , July 1982 in “British Journal of Dermatology”

Retinol acetate can reduce the harmful effects of the drug benoxaprofen on white blood cells.

research Experimental Evaluation of 3-meta-Pyridine-1,2,4-Oxadiazole Derivative of Deoxycholic Acid as a Prototype of 5-α-Reductase Inhibitors in In Silico and In Vivo Models

1 citations , February 2023 in “Russian Journal of Bioorganic Chemistry”

The new compound may be a safer alternative to finasteride for prostate protection.

FeCl3-Catalyzed C-N Coupling Reaction Between Cyclic Ethers and Heterocyclic Amines

research FeCl3-catalysed C-N coupling reaction between cyclic ethers and heterocyclic amines

4 citations , December 2014 in “European Journal of Chemistry”

Iron chloride helps create compounds that could be useful in medicine, like treating hair loss.

research Moving Chemoprevention Forward into the Most Promising Areas of Study

March 2003 in “Oncology Times”

Further research is needed to develop effective cancer prevention strategies.

research Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

65 citations , March 2004 in “Journal of Clinical Investigation”

Inhibiting ornithine decarboxylase may help prevent certain skin cancers.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

88 citations , February 2008 in “Journal of Medicinal Chemistry”

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

research Protoporphyrin IX: the Good, the Bad, and the Ugly

138 citations , November 2015 in “Journal of Pharmacology and Experimental Therapeutics”

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

research Synthesis of avicequinone c and analogs toward the study of 5α-reductase inhibitory activity

January 2015

2-Hydroxy-1,4-naphthoquinone is a strong 5α-reductase inhibitor.

research Alkylating Agents

November 2013

Alkylating agents can kill cancer cells but may cause skin and allergic reactions.

research Bioorthogonal Catalytic Microneedles Based on a Cytotoxic PEI Matrix for Synergistic Melanoma Therapy

April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

A new microneedle patch significantly improves melanoma treatment by using a special material to activate cancer-fighting drugs and disrupt cancer cells.

research Anthracycline analogs The past, present, and future

168 citations , December 1986 in “Cancer Chemotherapy and Pharmacology”

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

research Arsenic Trioxide as Effective Therapy for Relapsed Acute Promyelocytic Leukemia

22 citations , November 2002 in “Clinical journal of oncology nursing”

Arsenic trioxide effectively treats relapsed acute promyelocytic leukemia with manageable side effects.

research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

18 citations , December 2005 in “Journal of Medicinal Chemistry”

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

67 citations , September 2001 in “American Journal Of Pathology”

Inhibiting ODC can prevent UV-induced skin cancer.

research Topical spermine and putrescine stimulated DNA synthesis in the hairless mouse epidermis

10 citations , July 1980 in “British Journal of Dermatology”

Topical putrescine and spermine increased DNA synthesis in hairless mouse skin.

Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1

12 citations , June 2001 in “Bioorganic & Medicinal Chemistry”

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

research Milestones in Photocarcinogenesis

29 citations , July 2013 in “Journal of Investigative Dermatology”

UV radiation causes skin cancer, but sunscreens and certain drugs can help prevent it.

research Molecular, immunological, enzymatic and biochemical studies of coproporphyrinogen oxidase deficiency in a family with hereditary coproporphyria.

9 citations , February 2002 in “PubMed”

A new gene mutation causes hereditary coproporphyria with reduced enzyme activity.

research Targeted Therapy– and Chemotherapy-Associated Skin Toxicities: Systematic Review and Meta-Analysis

6 citations , August 2020 in “Oncology nursing forum”

Minocycline reduces acne rash, pyridoxine lowers hand-foot syndrome risk, and scalp cooling lessens hair loss from cancer treatments.

research Patent Evaluation: Hexahydrobenzo[f]quinolines as 5α-reductase inhibitors

June 1993 in “Current opinion in therapeutic patents”

Hexahydrobenzo[f]quinolines are effective at blocking the enzyme 5α-reductase.

research The protoporphyrin IX dimethyl ester incorporated soy lecithin for photoinactivation of fluconazole-resistant Candida albicans

September 2015 in “Photodiagnosis and Photodynamic Therapy”

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease

86 citations , November 2015 in “Journal of Gastroenterology”

The NUDT15 R139C variant causes thiopurine-induced leukocytopenia through a different mechanism than previously thought in Japanese patients with inflammatory bowel disease.

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