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Creating evidence-based guidelines for gender incongruence is difficult due to the personalized nature of transgender medicine.

Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.

Hormone treatment for transsexual individuals is effective but carries risks like thromboembolic events and mood changes, with most side effects being minor and reversible.

Dermatopathologists must consider both birth sex and gender identity to accurately diagnose and treat transgender patients.

Polycystic Ovary Syndrome (PCOS) affects Iranian women's feelings of femininity and self-image.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Medical care for transgender youth should be individualized and supportive.

The document concludes that careful planning and execution of facial gender affirmation surgery after at least 12 months of hormonal therapy can improve the quality of life for transgender individuals.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Orthognathic surgeons play a key role in modifying masculine facial features to be more feminine, often improving transgender women's quality of life.

Gender-affirming hormone therapy and surgery affect gut bacteria differently.

Parental support and gender-affirming care are crucial for the mental health of transgender adolescents.

Most transgender adolescents continued hormone treatment, with few stopping due to reasons other than returning to their birth gender.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Dermatologists are important in helping transgender people with skin issues and physical changes during their transition.

The document concludes that transsexual individuals often experience improved quality of life after transitioning, despite higher risks of psychiatric issues and mortality.

Hormonal therapy changes skin and hair in transgender patients, who need better researched dermatologic care.

Primary care providers should understand Geschlechtsinkongruenz to offer better care for transitioning individuals.

Improved access to hair removal is crucial for transgender individuals before feminizing surgeries.

Hormonal therapy in transgender patients can lead to skin changes like altered sebum production, hair growth, and acne, which may require dermatological care.

Cyproterone acetate is a safe treatment that causes mild feminizing effects and is more effective with added estrogens.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

A 31-year-old woman was diagnosed with Complete Androgen Insensitivity Syndrome much later than usual, leading to a call for earlier detection and treatment guidelines.

Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.

Transgender patients use hair restoration surgery to match their hairline with their gender identity.

More research is needed to improve lower body gender affirmation techniques.

A multidisciplinary approach is crucial for safe and effective hormone treatment in gender-dysphoric individuals, with specific guidelines for adolescents and adults.

Hair restoration helps transgender patients achieve desired gender appearances.

Inclusive and culturally competent healthcare is crucial for transgender and non-binary individuals.