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The malignant pilomatricoma showed strong epithelial keratin expression, suggesting it may not calcify.

LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.

Deleting the MAD2L1 gene in mice led to rapid tumor growth despite chromosomal instability.

Overexpression of Hoxc13 in hair cells causes hair loss and skin issues.

Increased methylation of the Filip1l gene may contribute to aggressive skin cancer.

Only one K16 gene on chromosome 17 makes a functional keratin protein.

The HCR gene contributes to psoriasis risk.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.

KRT17 may be a new target for endometrial cancer treatment because it helps cancer cells move and form new blood vessels.

The gene LRRC15 is more active in balding areas of the scalp compared to non-balding areas.

A 4kb fragment of the desmocollin 3 promoter targets gene expression to specific skin and hair follicle areas.

Deleting the CD271 gene in mouse skin cells leads to disorganized skin and increased hair growth, suggesting CD271 is important for skin health.

CTCF protein is essential for skin and hair follicle development in mice.

Targeting Keratin 17 may help overcome cancer therapy resistance.

Deleting the MAD2L1 gene is tolerated in certain mouse cancer models.

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

CK 5/6 expression in breast cancer is linked to negative hormone receptor status and higher tumor grade.

New mouse models help study melanocytic cells for melanoma research.

High levels of human keratin 16 in mice cause skin lesions and abnormal skin development.

Truncated hHb1 keratin may play a role in breast cancer cell transformation.

Mouse and human keratin 16 can both form filaments, with differences likely due to the tail domain, not the helical domain.

Mutations in the KRT16 gene can cause skin and nail disorders.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

c-Kit is important for heart regeneration and cancer development.

The mK6irs1/Krt2-6g gene likely causes wavy hair in mice.

The K14 promoter is more active in skin cells than the K5 promoter.

Keratin 17 is important for hair and nail structure and affects pachyonychia congenita symptoms.

The system allows precise control of gene expression in mouse skin, useful for studying skin biology.