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GlossaryCollagen

protein providing structure and strength to connective tissues

Collagen is a protein that serves as a key structural component in various connective tissues, including skin, hair, nails, bones, and tendons. It provides strength and elasticity, helping to maintain the integrity and resilience of these tissues. As we age, collagen production decreases, which can lead to signs of aging such as wrinkles and weakened joints.

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Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research 583 Induction of type 17 collagen decreases ultraviolet b-induced cellular senescence in human htert/ker-ct keratinocytes

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Increasing type 17 collagen reduces aging signs in skin cells caused by UV light.

research Promoting effect of type 17 collagen production by chlorogenic acid using PLGA nanoparticles in the human epidermal keratinocyte cell

8 citations , February 2020 in “Journal of Drug Delivery Science and Technology”

Encapsulating chlorogenic acid in nanoparticles boosts type 17 collagen production, potentially aiding skin care.

research Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair

9 citations , January 2022 in “Theranostics”

Collagen XVII is important for skin aging and wound healing.

research Niche work when you can get it: collagen XVII and the melanocyte stem cell

2 citations , May 2011 in “Pigment Cell & Melanoma Research”

Collagen XVII is crucial for preventing hair and pigmentation loss by maintaining melanocyte stem cells.

research The relevance of collagen XVII expression in epidermal differentiation and proliferation

September 2016 in “Journal of dermatological science”

Collagen XVII is crucial for skin cell growth and nail health.

research Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions

34 citations , January 2022 in “Frontiers in Immunology”

IL-25 helps heal diabetic wounds by improving blood vessel and skin cell functions.

Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

research Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

9 citations , September 2017 in “Nanoscale Research Letters”

Graphene oxide helps deliver a skin healing agent over time, improving skin and hair follicle regeneration.

Collagen Hydrolysate from Mozambique Tilapia Scales Improves Hair and Skin Health

research Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

2 citations , August 2023 in “Marine drugs”

Collagen from tilapia scales may improve hair and skin health by reducing stress and inflammation and encouraging hair growth.

Effects of Glucagon-Like Peptide-1 Receptor Agonists on Skin Homeostasis and Aging Processes

research Effects of Glucagon-like Peptide-1 Receptor Agonists on Skin Homeostasis and Skin Aging Processes

April 2026 in “Journal of Clinical Medicine”

GLP-1 RAs may help wound healing but can also cause faster facial aging and skin issues.

Management of Chemotherapy-Induced Alopecia Using a Topical Botanical Lotion via a Proposed Triple-Action on Apoptosis, Inflammation, and Collagen

research Abstract 3478: Management of chemotherapy induced alopecia using a topical botanical lotion via a proposed triple-action on apoptosis, inflammation and collagen

July 2016 in “Cancer Research”

A topical lotion helped manage hair loss from chemotherapy by affecting cell death, inflammation, and collagen, with no side effects.

Effects of Collagen Type XVII Alpha 1 on Epidermal Stem Cells in Aging Skin and the MicroRNA Intervention Mechanism

research [Effects of collagen type ⅩⅦ α1 on epidermal stem cells in aging skin and the microRNA intervention mechanism].

September 2022 in “PubMed”

Collagen type XVII α1 decreases with age, leading to skin aging, but targeting microRNA-203b-3p may help maintain its levels and improve skin health.

research 17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α

38 citations , May 2010 in “American Journal Of Pathology”

17β-Estradiol slows wound healing in male mice through estrogen receptor-α.

research Antiaging effects of equol: A unique antiandrogenic isoflavone metabolite and its influence in stimulating collagen deposition in human dermal monolayer fibroblasts

2 citations , March 2005 in “Journal of the American Academy of Dermatology”

Equol may help with antiaging and skin health by boosting collagen and blocking certain hormones.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

283 citations , February 2011 in “Cell stem cell”

COL17A1 is crucial for preventing hair graying and loss by supporting hair and pigment stem cells.

research Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo

21 citations , November 2023 in “International Journal of Molecular Sciences”

Melatonin helps reduce aging signs in human eyelid skin.

research Stem cell niche: from concept to reality

1 citations , January 2012 in “Pigment Cell & Melanoma Research”

Stem cell niches are crucial for maintaining stem cells, with Paneth cells and TGF-beta playing key roles.

Hair Follicle Rejuvenation Induced by Topical Minoxidil in a Humanized Mouse Model of Androgenetic Alopecia

research 508 Hair follicle rejuvenation is induced by topical minoxidil administration in a humanized mouse model of androgenetic alopecia

November 2024 in “Journal of Investigative Dermatology”

Minoxidil rejuvenates hair follicles and reduces aging signs in male pattern baldness.

research 52814 Minoxidil exerts skin rejuvenation effects in human androgenetic alopecia xenotransplants in vivo

September 2024 in “Journal of the American Academy of Dermatology”

Minoxidil helps hair regrowth and has anti-aging effects on hair follicles.

Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

research 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

research MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment

32 citations , July 2017 in “Molecular diagnosis & therapy”

MicroRNA-21 could help diagnose and treat skin fibrosis.

research Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles

26 citations , April 2024 in “Particle and Fibre Toxicology”

Nanoplastics can penetrate skin cells, triggering inflammation and immune responses.

research Interventions for morphea

24 citations , July 2019 in “Cochrane library”

Some treatments like methotrexate with prednisone might help juvenile morphea, but more research is needed to confirm.

research Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging

14 citations , December 2020 in “Journal of Investigative Dermatology”

Aging causes changes in the scalp that can affect hair growth and lead to older-looking hair in women.

research Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue

8 citations , November 2019 in “Clinical Science”

High DHA levels delay wound healing and worsen skin repair quality.

research Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis

7 citations , February 2019 in “Journal of pharmacological sciences”

Bazhengsan reduces inflammation and tissue growth in chronic prostatitis.