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GlossaryConnective Tissue

biological tissue that supports, connects, or separates other tissues

Connective tissue is a type of biological tissue that supports, connects, or separates different types of tissues and organs in the body. It includes various components such as collagen fibers, elastic fibers, and ground substance, and can be found in forms like bone, blood, and adipose tissue. This tissue plays a crucial role in providing structural integrity, facilitating nutrient transport, and protecting organs.

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Single-Cell Transcriptomics Reveals Hair Growth Retardation Mediated by Aberrant Connective Tissue Sheath Contraction in Male Androgenetic Alopecia

research Single-cell transcriptomics reveals hair growth retardation mediated by aberrant connective tissue sheath contraction in male androgenetic alopecia

February 2026 in “Nature Communications”

Inhibiting connective tissue sheath contraction may improve hair growth in male pattern baldness.

Aberrant Connective Tissue Sheath Contraction Drives Premature Hair Follicle Regression by Inducing Progenitor Cell Depletion in Androgenetic Alopecia

research Aberrant connective tissue sheath contraction drives premature hair follicle regression by inducing progenitor cell depletion in androgenetic alopecia

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Abnormal contraction of connective tissue in hair follicles causes hair loss by killing off important cells, and treating this could improve hair growth.

ELife Assessment: The Drosophila Hematopoietic Niche Assembles Through Collective Cell Migration Controlled by Neighbor Tissues and Slit-Robo Signaling

research eLife Assessment: The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling

January 2025

Proper niche formation in Drosophila requires Slit-Robo signaling for cell migration.

research Neural crest cells give rise to non-myogenic mesenchymal tissue in the adult murid ear pinna

1 citations , August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Certain cells in the adult mouse ear come from cranial neural crest cells, but muscle and hair cells do not.

research Connective tissue sheath of hair follicle is a major source of dermal type I procollagen in human scalp

4 citations , September 2012 in “Journal of dermatological science”

The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.

research 606 Connecting signaling dynamics with cell fates in live mice

April 2021 in “Journal of Investigative Dermatology”

Stem cells control their future role by changing ERK signal timing, affecting tissue regeneration and cancer.

research Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis

25 citations , April 2021 in “The EMBO Journal”

Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.

research Hair follicle stem cells: Walking the maze

165 citations , June 2007 in “European Journal of Cell Biology”

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

research Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis

95 citations , July 2010 in “Genes & development”

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

research Hair follicle neogenesis induced by cultured human scalp dermal papilla cells

63 citations , September 2009 in “Regenerative Medicine”

Scientists found a way to grow human hair cells in a lab that can create new hair when transplanted.

research Enhanced Expansion and Sustained Inductive Function of Skin-Derived Precursor Cells in Computer-Controlled Stirred Suspension Bioreactors

17 citations , September 2016 in “Stem cells translational medicine”

Using bioreactors, scientists can grow more skin stem cells that keep their ability to regenerate skin and hair.

research Ability to culture dermal papilla cells from red deer (Cervus elaphus) hair follicles with differing hormonal responses in vivo offers a new model for studying the control of hair follicle biology

16 citations , August 1996 in “The journal of experimental zoology/Journal of experimental zoology”

Red deer hair cells offer a new way to study how hormones affect hair growth.

research Expression of melanocortin receptors on cutaneous fibroblastic cells – collagen and beyond

1 citations , January 2005 in “Experimental Dermatology”

MC-1R in skin cells may influence inflammation and collagen production.

research Faculty Opinions recommendation of De novo production of dermal papilla cells during the anagen phase of the hair cycle.

December 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

New cells join the hair's dermal papilla during the growth phase, possibly affecting hair thickness.

Establishment of SV40T-Transformed Human Dermal Papilla Cells and Identification of Dihydrotestosterone-Regulated Genes by cDNA Microarray

research Establishment of SV40T-transformed human dermal papilla cells and identification of dihydrotestosterone-regulated genes by cDNA microarray

13 citations , June 2007 in “Journal of Dermatological Science”

Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.

research Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies

30 citations , April 2017 in “Experimental Dermatology”

Hair follicle stem cells and skin cells show promise for hair and skin therapies but need more research for clinical use.

Granulation Tissue Developed After Minor Trauma in a Psoriatic Patient on Long-Term Etretinate Therapy

research Granulation Tissue that Developed after a Minor Trauma in a Psoriatic Patient on Long-term Etretinate Therapy

10 citations , March 1990 in “The Journal of Dermatology”

Long-term etretinate use may cause delayed wound healing and extra tissue growth after injury.

research Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study

6 citations , September 2019 in “Skin pharmacology and physiology”

RCS-01 therapy is safe and may improve skin structure by affecting gene expression.

research Folliculosebaceous Cystic Hamartoma with Spindle Cell Lipomatous and Neural Components

June 2023 in “Dermatopathology”

A woman had a unique skin growth with hair follicle, oil glands, fat cells, spindle cells, and nerve fibers.

research Adipose and Hair Function: An aPPARent Connection

7 citations , February 2018 in “Journal of Investigative Dermatology”

Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.

research Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior

42 citations , January 2014 in “Cold Spring Harbor Perspectives in Medicine”

Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.

research Mechanotransduction in Androgenetic Alopecia: An In Silico Repositioning Study of PIEZO1 + MLCK Axis Using Cofolding and Pilosebaceous Single-Cell Atlas Constraints

January 2026 in “Open MIND”

Targeting the PIEZO1 and MLCK axis may offer a new treatment for hair loss.

research Sheep vibrissa dermal papillae induce hair follicle formation in heterotypic skin equivalents

21 citations , December 1994 in “British Journal of Dermatology”

Sheep dermal papillae can help form hair follicles in skin models.

Particulate Matter Exposure Induces Maternal Scalp Hair Loss After Birth in C57/B6 Mouse via Alteration of Inflammatory and Apoptotic Pathways

research Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways

May 2026 in “Frontiers in Endocrinology”

Exposure to particulate matter worsens postpartum hair loss by affecting inflammation and cell death pathways.

research Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals