138 citations
,
March 2001 in “Clinics in Dermatology” Hair loss can significantly affect a person's self-esteem and body image, especially in young people, those who value their looks highly, and women.
136 citations
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March 1998 in “Oncogene” Overexpression of E2F1 can lead to skin tumors and disrupt hair growth.
127 citations
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November 2010 in “Pigment cell & melanoma research” We need more research on human hair follicle pigmentation, not just mouse models.
124 citations
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February 2018 in “Nature Reviews Genetics” Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.
102 citations
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December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Restoring hair bulb immune privilege is crucial for managing alopecia areata.
75 citations
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November 2007 in “Clinical endocrinology” Certain medications including flutamide, spironolactone, and others effectively reduce excessive hair growth in women, especially when combined with lifestyle changes.
72 citations
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December 2012 in “Expert Opinion on Drug Delivery” Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.
68 citations
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January 2008 in “Clinics in dermatology” Siddha medicine uses herbs and minerals to safely treat skin diseases like psoriasis and eczema.
66 citations
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September 2008 in “Dermatologic therapy” The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.
64 citations
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July 2016 in “Cold Spring Harbor Perspectives in Medicine” The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
63 citations
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January 2001 in “AIDS” Immune recovery after HIV treatment can cause autoimmune issues like hair loss and thyroid disease.
60 citations
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June 1997 in “Journal of The American Academy of Dermatology” Apoptosis is crucial for healthy skin and treating skin diseases.
57 citations
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March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
56 citations
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November 2016 in “Aesthetic surgery journal” The document concludes that the effectiveness of platelet rich plasma in aesthetic surgery is unclear due to inconsistent reporting and lack of objective measures in studies.
54 citations
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September 2005 in “Australasian Journal of Dermatology” Dermatologists are more accurate than general practitioners in diagnosing skin conditions, especially skin cancer.
48 citations
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December 2019 in “Reproductive Biology and Endocrinology” More research is needed to confirm sperm DNA fragmentation as a reliable tool for diagnosing male infertility.
47 citations
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May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology” The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.
44 citations
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October 2020 in “Arthritis Care & Research” Choosing the right tools is crucial for accurately measuring lupus activity and damage.
44 citations
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January 2018 in “The International Journal of Developmental Biology” Stem cells in the skin help with healing and can also lead to cancer.
44 citations
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September 2014 in “Cell Death & Differentiation” Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.
43 citations
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March 2011 in “Journal of psychosomatic research” Kids with alopecia areata may experience more stress but not necessarily feel more anxious or depressed than others.
39 citations
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March 1997 in “The Lancet” Acquired perforating dermatosis often affects skin in people with kidney issues and diabetes.
38 citations
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April 2005 in “Journal of Investigative Dermatology” Human hair follicle cells can become fat and bone cells, useful for therapy.
37 citations
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December 2014 in “Journal of Biomedical Informatics” Researchers created LabeledIn, a detailed list of drug uses, showing the importance of human input in making such lists.
37 citations
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October 2013 in “PLoS ONE” MicroRNAs play a key role in wool growth in Tibetan sheep.
35 citations
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December 2020 in “International Journal of Molecular Sciences” Mast cells likely promote skin scarring and fibrosis, but their exact role is still unclear.
35 citations
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June 2012 in “PloS one” Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.
33 citations
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February 2019 in “Journal of Tissue Engineering and Regenerative Medicine” Platelet-Rich Plasma (PRP) shows promise for treating various skin conditions, but more research is needed to standardize its use.
33 citations
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January 2018 in “The International Journal of Developmental Biology” Cell aging can be both good and bad for tissue repair.
31 citations
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December 2016 in “Anais Brasileiros de Dermatologia” DHEA reduction may be linked to frontal fibrosing alopecia, but more research is needed.