research Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas
Basal cell carcinomas and squamous cell carcinomas have different gene activity patterns, suggesting unique treatment approaches.
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810-840 / 1000+ resultsresearch Human bone marrow mesenchymal stem cells-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway
Exosomes from stem cells help wounds heal faster by affecting specific cell signals.
research Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis
Overexpressing follistatin in mice delays wound healing and reduces scar size.
research 866 Senescent fibroblasts secretome promote tumoural initiation of normal human keratinocytes through cellular activation, enhanced migration and ECM remodelling
Senescent fibroblasts can help start tumors in normal skin cells.
research Store-operated calcium channels in skin
Calcium channels are vital for normal skin function and their dysfunction can lead to skin issues.
research Jelátviteli mechanizmusok szerepe a bőr biológiai folyamatainak szabályozásában
Signaling mechanisms, including TRPV channels and cannabinoid receptors, are important in skin and hair biology.
research Lgr5 Stem Cells and Potential Treatments for Hair Loss
Targeting Lgr5+ stem cells and Wnt signaling may effectively treat hair loss.
research Insights into the context-dependent immunological roles of the CXCL12–CXCR4 axis in alopecia
Blocking the CXCL12–CXCR4 axis may help treat hair loss in alopecia.
research A New Role for an Old Friend: NFAT and Stem Cell Quiescence
NFATc1 is crucial for keeping hair follicle stem cells inactive.
research Role of regeneration in tissue repairing and therapies
The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.
research Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata
Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.
research The topography of fibrous scaffolds modulates the paracrine function of Ad-MSCs in the regeneration of skin tissues
The shape of fibrous scaffolds can improve how stem cells help heal skin.
research β-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes during Post-Traumatic Gliogenesis in the Adult Brain
β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.
research A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies
The model helps understand scar contraction and develop new treatments.
research Stress-induced chemokine production by hair follicles recruits dendritic cells to sites of minor trauma
Hair follicles help attract immune cells to minor skin injuries.
research Immunological control of skin development: from homeostasis to developmental pathologies
Immune cells are crucial for normal skin development and their dysfunction can cause skin disorders.
research Primary cicatricial alopecias are characterized by dysregulation of shared gene expression pathways
Similar treatments might work for different types of scarring hair loss.
research Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells
Wnt signaling is crucial for skin development and hair growth.
research Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin
Hair follicle development and microbes help regulatory T cells gather in newborn skin.
research Drugs targeting the JAK/STAT pathway for the treatment of immune-mediated inflammatory skin diseases: protocol for a scoping review
JAK/STAT inhibitors show promise for skin diseases but aren't yet approved.
research Transient stimulation of TRPMLs enhance the functionality of hDPCs and facilitate hair growth in mice
Activating TRPMLs helps human cells important for hair growth and increases hair growth in mice.
research Intradermal adipocytes mediate fibroblast recruitment during skin wound healing
Fat cells help recruit healing cells and build skin structure during wound healing.
research The Stem Cell Niche in Regenerative Medicine
Targeting and modifying the stem cell niche can improve regenerative therapies.
research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport
Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.
research A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells
Aging hair follicle stem cells can be rejuvenated by inhibiting Cdc42.
research Chaperones as thermodynamic sensors
New cancer treatments show promise in reducing tumor growth and improving skin regeneration in mice.
research The role of hair follicles and Edar signalling in cutaneous wound healing
Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.
research Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives
Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.
research Hedgehog signalling in skin development and cancer
The hedgehog signalling pathway is key in skin development and basal cell carcinoma, offering insights for prevention and treatment.
research Regulatory T cells in inflammatory skin disease: from mice to humans
Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.