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Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling

11 citations , August 2021 in “Stem Cell Research & Therapy”

Pimecrolimus reduces the effectiveness of stem cell therapy for atopic dermatitis.

research Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.

113 citations , May 2002 in “PubMed”

Overexpressing COX-2 in mice skin reduces skin tumor development.

research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression

41 citations , September 2003 in “Journal of Investigative Dermatology”

Overexpression of COX-2 causes early hair loss in mice, but can be prevented with a COX-2 inhibitor.

research Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase

25 citations , August 2015 in “Molecules”

Mimosine dipeptides are promising for treating hyperpigmentation and inflammation.

research Cyclooxygenases in the skin: pharmacological and toxicological implications

165 citations , September 2003 in “Toxicology and applied pharmacology”

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

research Clinical Snippets

1 citations , March 2003 in “Journal of Investigative Dermatology”

Early sunburn treatment with certain inhibitors may reduce skin cancer risk.

research Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage

1 citations , June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

UV exposure harms skin by causing fibroblast loss, but T cells help fibroblast survival.

research Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin

January 2025 in “Cellular & Molecular Biology Letters”

Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.

research The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

20 citations , August 2020 in “Scientific Reports”

Low-dose bisphenol A increases prostate size in rats by affecting certain enzymes.

research COX2-ATP Synthase Regulates Spine Follicle Size in Hedgehogs

January 2023 in “International journal of biological sciences”

COX2 and ATP synthase control the size of hedgehog spines.

Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E₂through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

9 citations , November 2012 in “Biomolecules & therapeutics”

A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.

research Chemical Constituents from Osmanthus fragrans var. aurantiacus Makino with Their In Vitro and In Silico Studies Target Anti-Inflammation by Suppressing ERK 1/2 MAPK Signaling

August 2025 in “International Journal of Molecular Sciences”

Osmanthus fragrans var. aurantiacus Makino may help treat inflammation due to its antioxidative and anti-inflammatory properties.

research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review

10 citations , August 2022 in “International Journal of Molecular Sciences”

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

research Ferulic Acid Induces Keratin 6α via Inhibition of Nuclear β-Catenin Accumulation and Activation of Nrf2 in Wound-Induced Inflammation

16 citations , April 2021 in “Biomedicines”

Ferulic acid helps wounds heal faster by reducing inflammation and promoting skin cell movement.

research Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways

March 2026 in “Molecules”

Camellia sinensis seed flavonoids can reduce skin inflammation and damage from UV rays.

UV Light May Induce Hypertrichosis Through Production of Prostaglandin E2

research UV light may induce hypertrichosis through production of PGE2

7 citations , October 2006 in “Medical hypotheses”

UV light might cause excessive hair growth by increasing PGE2 in the skin.

research Investigation of In Vitro and In Silico Anti-Inflammatory Potential of Carthamus caeruleus L. Root Juice

2 citations , June 2025 in “International Journal of Molecular Sciences”

Carthamus caeruleus root juice may reduce inflammation.

research A Concise Review on Biological Activity of Tridax procumbens Linn

1 citations , January 2017 in “Organic chemistry”

Tridax procumbens has medicinal properties like healing, pain relief, and infection control.

research A new target for squamous cell skin cancer?

6 citations , October 2014 in “Experimental Dermatology”

Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

research 전립선 비대유도 쥐의 전립선 조직에서 울금 급여에 따른 염증인자의 변화

October 2015 in “Journal of the East Asian Society of Dietary Life”

Curcuma longa L. may help reduce prostate inflammation.

research Functional Characterization of Callus Extracts of Apple 'Hirosaki' for Cosmetic Materials

August 2013 in “Han'gug saengmul gonghag hoeji/KSBB journal”

Apple 'Hirosaki' callus extracts may improve wrinkles, stimulate hair growth, and have anti-inflammatory effects for use in cosmetics.

research Editor's evaluation: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

June 2021

Different types of sun exposure damage skin cells and immune cells, with chronic exposure leading to more severe and lasting damage.

research 850 After skin wounding, noncoding dsRNA coordinates prostaglandins and WNT7b to promote regeneration

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Double stranded RNA helps skin wounds heal by coordinating specific proteins and signaling pathways.

research Ketoconazole-p Aminobenzoic Cocrystal Exhibits a Potent Anti-inflammatory Effect on the Skin of BALBc Mice

April 2021 in “Research Square (Research Square)”

The new cocrystal KET-PABA is a more effective and safe anti-inflammatory treatment for skin conditions in mice.

research Betulinic acid exerts anti‐hepatitis C virus activity via the suppression of NF‐κB‐ and MAPK‐ERK1/2‐mediated COX‐2 expression

44 citations , June 2015 in “British Journal of Pharmacology”

Betulinic acid can help treat hepatitis C by stopping virus replication.

research Pharmacophore Modeling and Three Dimensional Database Searching for Drug Design Using Catalyst: Recent Advances

153 citations , November 2004 in “Current Medicinal Chemistry”

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

research Effect of Fenugreek Extract on Testosterone Propionate-Induced Benign Prostatic Hyperplasia

January 2025 in “International Journal of Molecular Sciences”

Fenugreek extract may help treat benign prostatic hyperplasia.

research Contemporary drug synthesis

77 citations , December 2004 in “Choice Reviews Online”

The document summarized how various modern drugs are made.