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990-1000 / 1000+ resultsresearch Regulation of hard α-keratin mechanics via control of intermediate filament hydration: matrix squeeze revisited
Hard α-keratins stay stiff in water because the surrounding matrix keeps them dehydrated and strong.
research Supercritical CO2–Decellularized amniotic ECM hydrogel promotes immunomodulatory skin regeneration
The study introduces a decellularized porcine amniotic membrane (dPAM) hydrogel, engineered using supercritical carbon dioxide, which effectively removes immunogenic components while preserving bioactive molecules crucial for skin regeneration. The hydrogel promotes angiogenesis, reduces pro-inflammatory responses, and enhances regenerative signaling in human follicle-derived dermal papilla cells, indicating its potential to influence hair follicle biology. In a UVB-induced skin inflammation murine model, the hydrogel demonstrated dual functionality by reducing early immune responses and promoting tissue repair. These findings suggest that dPAM hydrogel could serve as a bioactive platform for cutaneous repair and broader regenerative applications.
research Trichohyalin: Purification from Porcine Tongue Epithelium and Characterization of the Native Protein
Trichohyalin, a protein from pig tongue, was purified and found to have a filamentous structure.
research Correction of Rhytides, Peau d’Orange, and Thin Dermis of the Face by Neocollagenesis Using Novel Collagen Stimulating Slurry Protocol
The new facial treatment improved wrinkles and skin thickness, with most patients seeing results within a month, despite some temporary swelling and bruising.
research Effect of varied hair protein fractions on the gel properties of keratin/chitosan hydrogels for the use in tissue engineering
Different hair protein amounts change the strength of keratin/chitosan gels, useful for making predictable tissue engineering materials.
research Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing
Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.
research Hollow polydopamine nanoparticles loading with peptide RL-QN15: a new pro-regenerative therapeutic agent for skin wounds
HPDAlR nanoparticles greatly improve skin wound healing without toxicity.
research JCD —Editorial for September 2023
The September 2023 issue highlights the importance of safety in cosmetic procedures and updates on treatments for acne, rosacea, and hair restoration.
research Baricitinib-loaded separable microneedle array patch (S-MAP) based on hyaluronic acid for alopecia areata therapy
The new microneedle patch effectively treats alopecia areata with fewer side effects than oral medication.