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Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

Tedisamil and glibenclamide affect cromakalim and minoxidil sulphate differently in rat aorta.

Some oral medications may help treat central serous chorioretinopathy, especially eplerenone, but more research is needed.

ARQ-234, a protein designed to treat atopic dermatitis, shows increased effectiveness in early testing.

Targeting NCoR1 can help treat heart enlargement and dysfunction.

Some synthetic carbohydrate receptors, especially compounds 3 and 15, show strong potential for treating Zika virus.

Targeting NETs may help reduce fibrosis in Crohn's disease.

Therapies targeting the androgen receptor are being developed to treat prostate cancer and improve bone and muscle health.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

CTHRC1 helps sweat glands recover by rebuilding nearby blood vessels.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Brepocitinib improves cicatricial alopecia and reduces key immune markers.

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

Block and replace therapy improved symptoms in recurrent cyclic Cushing’s disease.

Targeted protein degraders show promise in treating cancer but need to target more diverse proteins.

PTHRP agonists can stimulate hair growth, especially in damaged follicles, while antagonists may initially increase growth but ultimately inhibit it.

Cepharanthine may help treat COVID-19 by targeting similar pathways as other inflammatory diseases.

These migraine prevention drugs can cause side effects like constipation, hair loss, injection site reactions, fatigue, and sometimes unexpected issues like Raynaud's phenomenon and weight gain.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

Blocking CRF-R1 can reduce alcohol intake in stressed mice.

Metyrapone effectively stabilizes severe Cushing's disease symptoms before surgery.

Blocking CCR5 can prevent and improve hair loss in alopecia areata.

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

PROTACs offer new ways to treat hard-to-target diseases, with promising drugs for cancer in advanced trials.