42 citations
,
February 2021 in “Signal Transduction and Targeted Therapy” Hair follicle regeneration possible, more research needed.
42 citations
,
December 2014 in “Clinical, cosmetic and investigational dermatology” Nonablative radiofrequency treatments, especially microneedle and fractional types, can improve acne scars by 25%–75% after 3-4 sessions, with full results in 3 months and some side effects.
276 citations
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December 2017 in “Journal of Dermatological Science” The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.
120 citations
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October 2007 in “Clinical Interventions in Aging” Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.
65 citations
,
June 2020 in “Stem Cell Research & Therapy” Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.
47 citations
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April 2000 in “The American journal of pathology” Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.
41 citations
,
June 2010 in “Clinics in Dermatology” Smoking harms skin health, causing slower wound healing, more wrinkles, and worsening some skin conditions, but may protect against certain others.
21 citations
,
March 2019 in “Experimental Dermatology” Immune cells around hair follicles help control hair growth and could be targets for treating hair disorders.
17 citations
,
November 2018 in “Dermatology” Most patients with frontal fibrosing alopecia had facial bumps, with Hispanic/Latino and premenopausal women being more affected, suggesting a more severe condition.
14 citations
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September 2015 in “Ophthalmic plastic and reconstructive surgery” Surgical removal of abnormal fat pads fixed the woman's eyelid issue caused by likely silicone injections.
10 citations
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January 2018 in “Elsevier eBooks” Burn scars heal abnormally and more research is needed to find better treatments.
April 2026 in “International Journal of Impotence Research” Anabolic steroid abuse can cause sexual, fertility, and health problems.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” Researchers created a 3D-printed skin model that grew human hair when grafted onto mice by improving blood supply to the grafts.
211 citations
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February 2009 in “European journal of pharmaceutics and biopharmaceutics” Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.
130 citations
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August 2015 in “Experimental Dermatology” Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.
2 citations
,
March 2021 in “Molecular Immunology” Dermal macrophages might help regrow hair.
January 2026 in “Archives of Internal Medicine Research” PRP, exosomes, and physical therapies show promise for hair and tissue repair, but need more research for optimization.
305 citations
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March 2018 in “International journal of molecular sciences” The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.
220 citations
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March 2020 in “Advanced functional materials” Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.
146 citations
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July 2018 in “Regenerative Medicine” Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.
113 citations
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June 2015 in “Stem Cell Research & Therapy” Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
61 citations
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September 2020 in “Bioactive Materials” A special dressing called FEA-PCEI can speed up wound healing, reduce scars, and help grow new hair follicles, but only at the right dosage.
58 citations
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December 2017 in “Journal of The European Academy of Dermatology and Venereology” Microneedling can help stimulate hair growth, especially when used with other treatments, but it's not better than existing therapies.
31 citations
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April 2007 in “Experimental Dermatology” Stress in mice delays hair growth and treatments blocking substance P can partly reverse this effect.
30 citations
,
October 2016 in “Current research in translational medicine” Hair follicles on the scalp interact with and respond to the nervous system, influencing their own behavior and growth.
28 citations
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January 2016 in “Vitamins and hormones” Thymosin β4 helps improve skin healing and reduce scarring.
27 citations
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May 2016 in “Dermatologic Surgery” Male faces age with more wrinkles and hair loss, influenced by both body changes and environmental factors.
24 citations
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September 2018 in “Journal of Materials Science: Materials in Medicine” Hyaluronic acid-based HA2 hydrogel helps heal skin wounds better with less scarring.
22 citations
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January 2015 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” Platelet-rich plasma might help with skin aging, ulcers, and hair loss, but more research is needed to prove its effectiveness and safety.
22 citations
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November 2014 in “Psychiatric Clinics of North America” Stress can worsen skin conditions and affect mental health, so doctors should include stress management in skin treatment.