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GlossaryCuticle Cells

outermost layer of hair, protecting inner structures

Cuticle cells are the outermost layer of cells on a hair strand, forming a protective barrier. These cells overlap like shingles on a roof, helping to shield the inner layers of the hair from damage and moisture loss. For professionals, understanding the condition of cuticle cells is crucial for assessing hair health and determining appropriate treatments.

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Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

research Facile and Efficient Enzymatic Methods for Harvesting or Removal of Cuticle Cells from Human Hair Shafts

December 2021 in “Journal of natural fibers”

The conclusion is that new methods for isolating hair cuticle cells and removing the cuticle layer are effective and convenient.

research Scanning Electron Microscope Evaluation of Hair Dye Effects on the Cuticle Cells of Canine Hair

August 1985 in “Proceedings ... annual meeting, Electron Microscopy Society of America/Proceedings, annual meeting, Electron Microscopy Society of America”

Hair dye can damage dog hair and cause health issues.

research Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy

10 citations , January 2010 in “International journal of trichology”

Keratin-associated proteins are part of the developing hair fiber cuticle.

research Hair Pores Caused by Surfactants via the Cell Membrane Complex and a Prevention Strategy through the Use of Cuticle Sealing

1 citations , November 2023 in “Cosmetics”

Surfactants damage hair, but sealing the cuticle can prevent this.

research Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle.

44 citations , August 1990 in “PubMed”

Keratins K1 and K10 are found in the inner root sheath and cuticle of human hair follicles.

research Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis

68 citations , August 2014 in “PeerJ”

Human hair proteins vary by individual, body site, and ethnicity, useful for forensics.

research Hair cuticle differences between Asian and Caucasian females

21 citations , October 2006 in “International Journal of Dermatology”

Asian hair is stronger and more damage-resistant than Caucasian hair due to a thicker cuticle layer.

research A STUDY OF THE DIFFERENTIATION PRODUCTS OF THE HAIR FOLLICLE CELLS WITH THE ELECTRON MICROSCOPE.

19 citations , July 1964 in “PubMed”

Hair follicle cells become four types: medulla, cortex, cuticle, and inner root sheath.

research The cell membrane complex: Three related but different cellular cohesion components of mammalian hair fibers

15 citations , May 2010 in “International Journal of Cosmetic Science”

The cell membrane complex in mammalian hair has three distinct types with different structures and chemical properties.

research Histochemical observation of the cell membrane complex of hair.

15 citations , January 1992 in “Sen'i Gakkaishi”

The Cell Membrane Complex in hair has both water-attracting and water-repelling layers.

Analyzing the Laser-Light Reflection from Human Hair Fibers: Light Components Underlying the Goniophotometric Curves and Fiber Cuticle Angles

research Analyzing the laser-light reflection from human hair fibers. I. Light components underlying the goniophotometric curves and fiber cuticle angles.

3 citations , July 2003 in “PubMed”

The research found a way to measure hair surface changes by analyzing how light reflects off of it, and determined hair cuticle angles vary by hair length and color.

A Discrete Transition Zone Between Cuticle and Cortex Layers of a Human Hair Fiber: Changes Observed in the Presence of Breast Cancer

research A discrete transition zone between cuticle and cortex layers of a human hair fibre: changes observed in the presence of breast cancer

1 citations , October 2017 in “ecancermedicalscience”

Breast cancer alters specific molecular structures in hair, which revert after cancer removal.

research Progenitor‐cell‐enriched micrografts as a novel option for the management of androgenetic alopecia

14 citations , October 2019 in “Journal of Cellular Physiology”

Micrografts promote hair growth in androgenetic alopecia treatment.

research Fine Structure of the Fully Keratinized Hair Cuticle in the Head Hair of the Human

11 citations , January 1981 in “Cells Tissues Organs”

Human hair cuticle has five cell layers with specific junctions and granules.

research Age‐dependent changes in damage processes of hair cuticle

20 citations , January 2015 in “Journal of cosmetic dermatology”

Older people's hair cuticles get more easily damaged and lose protective oils, especially in their 40s and 50s.

research A highly resistant structure between the cuticle and the cortex of human hair. II. CARB, a penetration barrier

6 citations , December 2018 in “International Journal of Cosmetic Science”

CARB is a strong barrier in human hair that prevents dye penetration.

research Acid phosphatase distribution in the wool follicle. III. Fate of organelles in keratinized cells

6 citations , June 1976 in “Journal of ultrastructure research”

Keratinized wool cells still have some organelles like lysosomes and mitochondria.

research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

4 citations , January 2017 in “Biological & pharmaceutical bulletin”

Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.

research A novel monoclonal antibody to the outer root sheath cells

3 citations , October 1994 in “Journal of Dermatological Science”

The new antibody, TYHF-1, specifically targets certain hair-related structures.

research Epithelial barrier function: assembly and structural features of the cornified cell envelope

425 citations , August 2002 in “BioEssays”

The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.

Mesenchymal Stem Cell Exosome Therapy for Acquired Trichorrhexis Nodosa: A Case Series

research Mesenchymal Stem Cell Exosomes Therapy for Acquired Trichorrhexis Nodosa: A Case Series

November 2024 in “Journal of Cosmetic Dermatology”

MSC exosome therapy improved hair quality in patients with acquired trichorrhexis nodosa.

research μ-Crystallin, Thyroid Hormone-binding Protein, is Expressed Abundantly in the Murine Inner Root Sheath Cells

22 citations , September 2000 in “Journal of Investigative Dermatology”

μ-Crystallin may help hair growth by affecting thyroid hormone levels in mouse hair follicles.

research On Pathways for Small Molecules Into and Out of Human Hair Fibers

56 citations , January 1996 in “Journal of Forensic Sciences”

Dye enters hair at the edges of cuticle cells and penetrates more from water than alcohol-based solutions.

research Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: An ultrastructural study

31 citations , December 2010 in “Journal of the American Academy of Dermatology”

Loose anagen hair syndrome is caused by structural abnormalities in the hair follicle's inner root sheath.

research The structure of hair and follicles of mice carrying the naked (N) gene

21 citations , April 1982 in “Genetics Research”

Mice with the naked gene have missing or abnormal hair cells.

research Chapter 4 Cytomechanics of Hair

19 citations , January 2009 in “International review of cell and molecular biology”

Hair's strength and flexibility come from its protein structure and molecular interactions.

research Morphology and ultrastructure of antler velvet hair and body hair from red deer (Cervus elaphus)

18 citations , November 2010 in “Journal of morphology”

Antler velvet hair and body hair of red deer have different structures that help with protection and insulation.

Perspectives on Hair Evolution Based on Comparative Studies on Vertebrate Cornification

research Perspectives on Hair Evolution Based on Some Comparative Studies on Vertebrate Cornification

17 citations , June 2012 in “Journal of experimental zoology. Part B, Molecular and developmental evolution”

Hair in mammals likely evolved from glandular structures, not scales.

research Ultrastructural localization of hair keratins, high sulfur keratin-associated proteins and sulfhydryl oxidase in the human hair

9 citations , February 2016 in “Anatomical Science International”

Hair proteins change location and structure as hair cells mature.