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Did you mean Cyclin D1?

GlossaryCyclin D1

regulates cell cycle progression from G1 to S phase

Cyclin D1, also known as CCND1, is a protein that plays a crucial role in regulating the cell cycle, specifically the transition from the G1 phase to the S phase, where DNA replication occurs. It acts as a regulatory subunit for certain enzymes called cyclin-dependent kinases (CDKs), and its overexpression is often associated with various types of cancer, as it can lead to uncontrolled cell proliferation.

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research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

Fatigue, Alopecia, and Stomatitis Among Patients With Breast Cancer Receiving Cyclin-Dependent Kinase 4 and 6 Inhibitors: A Systematic Review and Meta-Analysis

research Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis

28 citations , July 2017 in “Expert Review of Anticancer Therapy”

Breast cancer patients taking CDK4/6 inhibitors are more likely to experience fatigue, hair loss, and mouth sores.

research RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling

21 citations , February 2017 in “PLoS ONE”

RhoA helps skin stem cells grow, aiding wound healing.

research Cyclin-dependent kinase inhibitors, p21waf1/cip1 and p27kip1, are expressed site- and hair cycle-dependently in rat hair follicles

9 citations , February 2001 in “Journal of Dermatological Science”

p21waf1/cip1 and p27kip1 help in hair follicle differentiation in rats.

research Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis

8 citations , July 2024 in “Journal of Advanced Research”

CDK inhibitors may help treat ARDS and psoriasis but need more testing for safety and effectiveness.

research Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

2 citations , July 2017 in “Oncology Letters”

Lacking cyclin D3 reduces skin cancer growth without affecting normal skin cell growth.

Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force Dermatology for Cancer Patients International Study

research Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study

1 citations , July 2023 in “Cancers”

Skin side effects from CDK4/6 inhibitors in breast cancer patients are generally mild and treatable, allowing most patients to continue treatment.

research Cyclin‐dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle

1 citations , January 2022 in “Cell Biology International”

Changing CDK4 levels affects the number of stem cells in mouse hair follicles.

research Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis

April 2010 in “Cancer Research”

CDK4 levels affect the number of hair follicle stem cells in mice.

research FGF18 signaling determines radioresistance of telogen hair follicles by the arrest of hair cycling

September 2016 in “Journal of dermatological science”

FGF18 helps hair follicles resist radiation by stopping hair growth cycles.

research Cyclic dynamics of hair follicles and the effect of minoxidil on the bald scalps of stumptailed macaques

54 citations , June 1985 in “American Journal of Dermatopathology”

Minoxidil helps grow longer, thicker hair in bald scalps of stumptailed macaques, and early treatment is more effective.

research Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells

7 citations , January 2013 in “BioMed research international”

Hair follicles and deer antlers regenerate similarly through stem cells and are influenced by hormones and growth factors.

research Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

16 citations , June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.

Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

research Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response

7 citations , September 2017 in “Scientific Reports”

Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.

Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells

research Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells.

August 1994 in “Molecular Endocrinology”

Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

research `Cyclic alopecia' inMsx2mutants: defects in hair cycling and hair shaft differentiation

158 citations , December 2002 in “Development”

Msx2-deficient mice experience irregular hair growth and loss due to disrupted hair cycle phases.

research The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice

73 citations , May 2009 in “Proceedings of the National Academy of Sciences”

Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.

research Micro-determination of cyclic AMP levels in human epidermis, dermis and hair follicles

19 citations , March 1975 in “British Journal of Dermatology”

A new method accurately measures cyclic AMP levels in small skin and hair samples.

research Cyclic Changes in the Metabolism of Estradiol by Rat Skin During the Hair Cycle**From the Departments of Dermatology and Biochemistry. University of Miami School of Medicine. Miami, Florida, 33136.

17 citations , August 1971 in “Journal of Investigative Dermatology”

research Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

8 citations , October 2020 in “International Journal of Molecular Sciences”

Nonanal from fruits and vegetables promotes hair growth by increasing growth factors.

research Cyclic ADP-Ribose Modulates Intracellular Calcium Homeostasis and Anagen-Associated Signaling Pathways in Human Hair Follicle Dermal Papilla Cells

January 2026 in “Applied Sciences”

Cyclic ADP-ribose helps regulate calcium and signals that promote hair growth in hair follicle cells.

research Cyclic combing of untreated and bleached human hair: Analysis of the time‐dependent breakage of hair through recording the formation of fibre fragments

September 2025 in “International Journal of Cosmetic Science”

Friction causes hair breakage during combing, and fragment count predicts hair strength.

research Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice

28 citations , May 2000 in “Proceedings of the National Academy of Sciences”

The Walleye dermal sarcoma virus cyclin causes excessive skin cell growth in mice.

research Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

211 citations , April 2013 in “Development”

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

research Molecular biology of hair morphogenesis: Development and cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

146 citations , May 2002 in “The American journal of pathology”

Cathepsin L is essential for normal hair growth and development.

research Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin

81 citations , January 2003 in “The FASEB Journal”

Follistatin helps hair growth and cycling, while activin prevents it.

research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations

41 citations , December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting MED1 in skin cells causes hair loss and skin changes.

research Activated Kras Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling

29 citations , October 2010 in “Journal of Investigative Dermatology”

Activating Kras in mouse skin causes excess skin and hair loss.

research Preferential crosstalk between perifollicular capillary vessels and dermal papilla cells during hair cycling homeostasis

April 2026 in “Scientific Reports”

Capillary and dermal papilla interactions are vital for hair growth and aging, with potential for treating hair loss.