Preferential Crosstalk Between Perifollicular Capillary Vessels and Dermal Papilla Cells During Hair Cycling Homeostasis

April 2026 in “ Scientific Reports ”

Ying Zeng, Akinari Abe, Satsuki Takashima, Miyu Kono, Reina Kagiyama, Mariko Komabayashi-Suzuki, Mariko Moriyama, Hiroyuki Moriyama, Tadashi Okamoto, H. Ando, Masaki Tanaka, Masamitsu Ichihashi, Masatsugu Ema, Ken‐ichi Mizutani

perifollicular capillary vessels dermal papilla cells hair cycling homeostasis minoxidil vascular endothelial cells angiogenic chemokine CCL2 vessel-DP crosstalk vascularization aging therapeutic targets hair loss skin disorders Rogaine

This study reveals the crucial interaction between perifollicular capillary vessels and dermal papilla (DP) cells in maintaining hair cycling homeostasis. It was found that capillaries around the DP adapt dynamically, with minoxidil enhancing their mobilization, while aging inhibits it. Vascular endothelial cells promote angiogenic chemokine expression, like CCL2, in DP cells, which is essential for vessel-DP crosstalk. CCL2 expression is cyclic and diminishes with age, and its neutralization impairs vascularization and DP function. These insights highlight the importance of vessel-DP interactions in hair cycling and aging, suggesting potential therapeutic targets for hair loss and skin disorders.

View this study on nature.com →

Discuss this study in the Community →

Research cited in this study

16 / 16 results

research Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging

May 2024 in “Journal of Advanced Research”

Communication between blood vessel and hair follicle cells decreases with age, affecting hair growth and blood vessel formation.

research New Target for Minoxidil in the Treatment of Androgenetic Alopecia

August 2023 in “Drug Design Development and Therapy”

Minoxidil may work for hair loss by reducing androgen sensitivity and altering hormone-related enzymes.

research Mechanical Stimuli-Induced CCL2 Restores Adult Mouse Cells to Regenerate Hair Follicles

18 citations , March 2023 in “Molecular Therapy — Nucleic Acids”

Mechanical stimuli and CCL2 can help regenerate hair follicles in adult mice.

research Vitamins and Their Derivatives Synergistically Promote Hair Shaft Elongation via PlGF/VEGFR-1 Signalling Activation

1 citations , September 2022 in “Journal of dermatological science”

Certain vitamins and their derivatives can help hair grow longer by activating specific growth signals.

research Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine

23 citations , January 2021 in “Scientific Reports”

Adding human blood vessel cells to hair follicle germs may improve hair growth and quality.

research Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo

44 citations , September 2019 in “The EMBO Journal”

Lymphatic vessels are essential for hair follicle growth and skin regeneration.

Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

research Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

46 citations , April 2016 in “Journal of Investigative Dermatology”

New genes found linked to balding, may help develop future treatments.

research Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

236 citations , April 2015 in “Cell”

Plucking some hairs can trigger nearby unplucked hairs to grow back more due to a collective response.

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

149 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”

The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.

research Perivascular Hair Follicle Stem Cells Associate With a Venule Annulus

51 citations , April 2013 in “Journal of Investigative Dermatology”

Hair follicle stem cells rely on nearby blood vessels for their maintenance and function.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , June 2012 in “Nature”

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

research Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation

240 citations , April 2011 in “Pigment Cell & Melanoma Research”

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

research Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells

45 citations , July 2006 in “Journal of Investigative Dermatology”

Chemotherapy affects blood vessels in hair follicles, not stem cells, allowing hair regrowth.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

Anti-Androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium Japonicum): Active Constituents Inhibiting Testosterone 5α-Reductase

research Anti-Androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium Japonicum): Active Constituents Inhibiting Testosterone 5α-Reductase

38 citations , January 2002 in “Biological & Pharmaceutical Bulletin”

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.