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The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

Cyproterone acetate and ethinylestradiol significantly lowered AMH levels in PCOS patients resistant to clomiphene.

CDK4/6 inhibitors affect safety and quality of life differently, requiring careful use.

Tyrosine kinase inhibitors effectively treat cancers but often cause skin and other side effects.

A specific gene variation increases the risk of high uric acid and cholesterol in young Mexican males.

34% of patients on hepatitis C treatment had reversible skin issues.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

Isotretinoin is recommended for acne treatment as it is as effective as cyproterone compound.

Genetic variants in CYP genes may worsen PCOS symptoms.

Cyclophosphamide likely causes skin darkening by affecting hair follicles.

Finasteride reduces certain behaviors caused by D1-like receptor agonists but not by D2-like receptor agonists in mice.

About half the patients treated with capecitabine and docetaxel developed severe hand-foot syndrome.

Two impurities in finasteride were identified and characterized as cyclohexyl and phenyl analogs.

Testing for the NUDT 15 variant is crucial before starting azathioprine, especially in Asians.

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

The guidelines ensure accurate genetic testing and reporting for 21-hydroxylase deficiency.

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

A new gene mutation causes hereditary coproporphyria with reduced enzyme activity.

SPET-085 effectively inhibits an enzyme linked to prostate issues, similar to finasteride.

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

The FDA warned about safety issues with remdesivir and tofacitinib, finasteride is linked to suicidality, potent topical corticosteroids increase osteoporosis risk, henna can cause hemolysis in G6PD deficiency, chemotherapeutic agents can cause adverse reactions, drug interactions are common in cancer patients, ketamine can reduce at-risk drinking, high dose of anticholinergics increases dementia risk in Parkinson's patients, and prenatal exposure to second-generation antipsychotics increases pregnancy complications.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

Peginterferon alfa-2b and ribavirin therapy for hepatitis C can cause serious side effects, some different from those reported in clinical trials.

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

Cyproterone acetate effectively treats virilized women, especially under 35, despite some side effects.

CTP-543 is generally safe for treating alopecia areata.

A cystic fibrosis patient developed Cushing's syndrome from a drug interaction between itraconazole and budesonide, which improved after stopping the medications.