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Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen ( HLA ) in 13 cases of familial frontal fibrosing alopecia: CYP 21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA ‐ A33:01 ; B14:02; C*08:02 as a genetic marker

7 citations , January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

research THE GENETICS OF CYP GENE VARIANTS IN ASSOCIATION WITH POLYCYSTIC OVARY SYNDROME: A NARRATIVE REVIEW

December 2024 in “Era s journal of medical research”

Genetic variants in CYP genes may worsen PCOS symptoms.

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

research Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

18 citations , October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

research Metabolite identification by mass spectrometry of the 5α-reductase inhibitor finasteride in vitro and in vivo

January 2009

Finasteride's metabolites were identified, helping understand how the drug is processed in the body.

research Synthesis of mimics of steroid A ring as potential enzyme inhibitors

September 2002 in “Research Repository (Kingston University London)”

Mimicking the steroid A-ring may help create effective enzyme inhibitors for prostate disease treatment.

research Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes

70 citations , March 2010 in “The Journal of Steroid Biochemistry and Molecular Biology”

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

research Simultaneous spectrophotometric determination of finasteride and tadalafil in recently FDA approved Entadfi™ capsules

3 citations , July 2022 in “BMC chemistry”

The methods accurately measure finasteride and tadalafil in Entadfi™ capsules for quality control.

Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

research Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition

98 citations , April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

research Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors

13 citations , January 2017 in “Chemical & Pharmaceutical Bulletin”

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

research 1424 METHYLATION AND DECREASED EXPRESSION OF 5-ALPHA REDUCTASE 2 IN HUMAN PROSATE SAMPLES: IMPLICATIONS FOR RESISTANCE TO THERAPY FOR BPH

March 2010 in “The Journal of Urology”

Methylation of the 5-AR2 gene may cause resistance to Finasteride in BPH patients.

research Rapid determination of finasteride in human plasma by UPLC–MS/MS and its application to clinical pharmacokinetic study

18 citations , April 2010 in “Journal of Chromatography B”

New method measures finasteride in blood quickly and accurately.

Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

research Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

38 citations , June 2018 in “Archives of Toxicology”

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

research Greater conversion of testosterone to 5α-dihydrotestosterone, reflecting increased peripheral 5α-reductase activity in nude mice treated with high doses of cyclosporine A

10 citations , August 1990 in “Journal of Steroid Biochemistry”

High doses of cyclosporine A increase testosterone conversion, possibly boosting hair growth.

Methylated CpG Dinucleotides in 5-Alpha Reductase 2 Gene Might Explain the Finasteride-Resistance in BPE Patients

research Methylated CpG dinucleotides in 5-α reductase 2 gene might explain the finasteride-resistance in BPE patients

July 2020 in “European urology open science”

Methylated gene parts may cause finasteride-resistance in some enlarged prostate patients.

research Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1

56 citations , December 2002 in “The Journal of Clinical Endocrinology & Metabolism”

Human bone cells mainly produce a type 1 enzyme that may help regulate bone health.

research Steroidogenesis of the testis – new genes and pathways

70 citations , April 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

research Chemical Mechanism of the Covalent Modification of 5.alpha.-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects

12 citations , March 1995 in “Journal of the American Chemical Society”

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

research Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

4 citations , December 2024 in “European Journal of Medicinal Chemistry”

New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.

Aromatase Deficiency in a Male Patient: Case Report and Literature Review

research Aromatase deficiency in a male patient - Case report and review of the literature.

36 citations , October 2016 in “Bone”

A male with aromatase deficiency improved bone health with estradiol treatment.

research Fatty acids and related lipid mediators in the regulation of cutaneous inflammation

28 citations , January 2018 in “Biochemical Society Transactions”

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

25 Years of Estrogen Receptor Beta: A Personal Journey

research 25 years of ERβ: a personal journey

11 citations , September 2021 in “Journal of molecular endocrinology”

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

research Isotretinoin

1 citations , March 2011 in “Informa Healthcare eBooks”

Isotretinoin is a preferred treatment for severe acne, often leading to long-term improvement, but requires careful monitoring due to potential side effects.