November 2009 in “Companion Animal” The document suggests that Alopecia X in dogs is mainly a cosmetic issue and might be better left untreated.
January 2021 in “Journal of clinical and cosmetic dermatology” Human skin responds to light with protective mechanisms, but more research is needed to understand these processes and their implications for health and therapy.
July 2021 in “PARIPEX INDIAN JOURNAL OF RESEARCH” Knuckle darkening can be an early sign of vitamin B12 deficiency.
119 citations
,
May 1987 in “The Journal of Dermatologic Surgery and Oncology” Most patients' skin darkening after sclerotherapy fades on its own within 6-24 months.
1 citations
,
December 2024 in “Case Reports in Dermatology” Cyclophosphamide likely causes skin darkening by affecting hair follicles.
71 citations
,
February 2006 in “Clinics in Dermatology” Pregnancy causes skin changes like darkening, hair thickening, nail changes, and increased risk of skin growths, most of which usually resolve after birth.
64 citations
,
June 1992 in “International Journal of Dermatology” Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.
36 citations
,
April 1990 in “Dermatologic Clinics” Most pregnant women experience skin changes like darkening and stretch marks, and some may have skin conditions that usually get better after giving birth.
24 citations
,
June 2011 in “International Journal of Dermatology” Most pregnant women experience skin changes like darkening and itching, while serious skin conditions are rare but need early treatment.
16 citations
,
February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
5 citations
,
August 2015 in “Sultan Qaboos University medical journal” Vitamin B12 deficiency can cause skin darkening and other symptoms, which improve with B12 supplements.
4 citations
,
March 2020 in “JAAD Case Reports” Vitamin B12 deficiency can cause darkening of all nails.
4 citations
,
October 2019 in “Skin Appendage Disorders” Gefitinib can cause hair and eyebrow darkening.
3 citations
,
August 2023 in “The Journal of Pediatrics” Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.
2 citations
,
October 2021 in “Clinical and experimental dermatology” Cyperus rotundus essential oil effectively treats underarm darkening, reduces inflammation, and slows hair growth.
June 2021 in “Asian Journal of Medical Sciences” Vitamin B12 deficiency can cause reversible skin darkening.
October 2019 in “International journal of research in dermatology” Misusing topical corticosteroids can cause skin darkening and other side effects.
40 citations
,
January 2013 in “Clinical Cosmetic and Investigational Dermatology” Desonide is more effective than niacinamide for reducing underarm darkening.
31 citations
,
February 1999 in “Dermatologic surgery” Sun exposure after laser hair removal can cause skin darkening, which is hard to treat and requires avoiding UV light.
21 citations
,
January 2007 in “Journal of the European Academy of Dermatology and Venereology” Travoprost can help eyelash growth but may cause darkening around the eyes.
12 citations
,
June 2010 in “Journal of dermatology” Some patients with severe alopecia areata developed skin darkening from their treatment, which may indicate a less effective response to the therapy.
4 citations
,
February 2022 in “Nutrients” Korean Red Ginseng saponins may protect skin from inflammation and darkening caused by air pollution.
2 citations
,
March 2020 in “Skin” Using cidofovir cream for a rare skin disease can cause skin darkening.
1 citations
,
January 2021 in “Journal of Dermatology and Dermatologic Surgery” Taking Vitamin D supplements may increase the risk of skin darkening after laser hair removal.
September 2021 in “CRC Press eBooks” Pregnancy can cause normal skin changes, including darkening of certain areas, nail changes, vascular changes, and breast changes like stretch marks.
15 citations
,
July 2004 in “AIDS” Indinavir therapy can cause reversible skin, hair, and nail darkening.
2 citations
,
November 2024 in “JAAD reviews.” Certain drugs can change hair color, either lightening or darkening it.
July 2025 in “The Egyptian Journal of Hospital Medicine” Both treatments improved alopecia areata, but methotrexate caused more skin darkening, while triamcinolone caused skin lightening and thinning.
January 2025 in “International journal of Indian medicine” Certain herbs in Ayurveda are effective for hair growth, darkening, and health.
April 2016 in “Journal of The American Academy of Dermatology” Women with PCOS often have more hair growth, skin darkening, and acne, which are linked to hormonal and metabolic issues.