The study introduces a novel approach for treating acute inflammatory visceral pain (AIVP) using dexmedetomidine-loaded hyaluronic acid hydrogel microneedles (MN/Dex). This method offers a minimally invasive, patient-friendly alternative to traditional intravenous administration, which can be uncomfortable and pose infection risks. The microneedles enable efficient skin penetration and controlled drug release, demonstrating excellent biocompatibility in biosafety evaluations. In a mouse model of AIVP, MN/Dex significantly reduced pain without causing sedation or affecting normal behaviors, suggesting its potential to improve outpatient management and quality of life for patients with AIVP.
April 2023 in “Journal of Investigative Dermatology” PX-12 may help treat psoriasis by blocking inflammation and cell death.
January 2026 in “Biomaterials Science” The formulation helps improve wound healing and skin repair.
65 citations
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January 2011 in “Frontiers in Endocrinology” Neurosteroids show promise for treating epilepsy and more research is needed.
1 citations
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January 2024 in “Skin research and technology” Deoxycholic acid is FDA-approved for reducing submental fat, but its mechanisms are not fully understood.
November 2022 in “Indian Journal of Dermatology/Indian journal of dermatology” Valproic acid can cause dark lines on nails.
September 2023 in “International journal of biological macromolecules” The chitosan/PDRN polyplex improved wound healing in diabetic rats.
1 citations
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May 2021 in “Scientific Reports” Certain cancer drugs are strongly linked to nerve damage, requiring close monitoring and early treatment.
36 citations
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August 2020 in “Polymers” The patch delivers more drugs through the skin effectively.
39 citations
,
May 2006 in “Molecular Plant-Microbe Interactions” Fusaric acid may help control Orobanche ramosa by activating plant defenses.
13 citations
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November 2005 in “Epilepsia” Deoxycorticosterone and its metabolites help prevent seizures by interacting with specific receptors.
January 2012 in “Journal of Cosmetics Dermatological Sciences and Applications” Iontophoresis greatly improves skin absorption of certain substances, especially in hairy mice.
46 citations
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April 1987 in “Brain Research” Hair-follicle nerves in cats' spinal cords can be inhibited by GABA-related connections.
January 2025 in “Regenerative Biomaterials” The hydrogel helps reduce scarring and improve wound healing by releasing salvianolic acid B in acidic conditions.
February 2023 in “European Journal of Medical Research” Certain existing drugs, like glycopyrronium and botulinum toxin type A, may help treat excessive sweating.
2 citations
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February 2023 in “Research Square (Research Square)” The scaffold effectively prevents melanoma relapse and aids wound healing.
September 2025 in “Frontiers in Pharmacology” The gel shows strong potential for effectively treating pressure ulcers.
April 2019 in “Journal of Investigative Dermatology” Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.
Convulsofin effectively treats primary epilepsy but has some side effects.
May 2018 in “Dermatologic Surgery” 
23 citations
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July 2003 in “Pharmacology, Biochemistry and Behavior” Finasteride blocks progesterone's effect on absence seizures in rats.
Calcium and hydrogen ions help root hair growth, while aluminum inhibits it.
January 1990 in “Springer eBooks” Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.
September 2002 in “Epiliepsy currents/Epilepsy currents” Stress increases neurosteroids that help prevent seizures.
26 citations
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July 2023 in “International Journal of Nanomedicine” The microneedle system shows promise for non-invasive brain drug delivery.
December 2015 in “Vascular Pharmacology” Prasugrel is better than clopidogrel at preventing heart damage and improving blood flow in small heart vessels during heart artery procedures.
10 citations
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January 2020 in “Acta Neurobiologiae Experimentalis” Valproic acid and crocin together boost cell growth and may help treat nerve injuries.
Ca²⁺-mediated protein citrullination controls cell growth in the CNS and may help treat brain tumors.
1 citations
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September 2017 in “Elsevier eBooks” Diuretics help the body get rid of excess salt and water by acting on the kidneys in different ways.
June 2025 in “Proceedings of the National Academy of Sciences” A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.