220 citations
,
March 2020 in “Advanced functional materials” Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.
172 citations
,
May 2018 in “Nature” Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.
41 citations
,
December 2019 in “Stem Cell Reviews and Reports” Tooth regeneration could become possible by controlling how and when bioactive factors are released.
28 citations
,
December 2012 in “The American Journal of Cosmetic Surgery” Proteins from stem cells improved hair growth in patients with hair loss.
19 citations
,
April 2015 in “Stem Cells” Pro-IGF-II improves muscle repair in old mice.
19 citations
,
November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” Human hair follicles can regenerate and recover after severe injury by going through a brief abnormal resting phase before growing again.
18 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.
12 citations
,
September 2021 in “The International Journal of Developmental Biology” Liposomal carriers can improve tissue regeneration by stabilizing and retaining growth factors.
10 citations
,
October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
8 citations
,
March 2019 in “Open Biology” The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.
1 citations
,
January 2024 in “Theranostics” Exosomes show promise for future tissue regeneration.
February 2024 in “Frontiers in physiology” Hair follicle stem cells help skin heal and grow during stretching.
June 2021 in “Experimental and Therapeutic Medicine” MEF/KSF-conditioned medium effectively grows mouse hair follicle stem cells with bone-forming potential.
April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” Certain small molecules can help regrow hair by turning on the body's cell cleanup process.
18 citations
,
November 2013 in “Molecules and Cells” New culture method keeps human skin stem cells more stem-like.
2 citations
,
November 2022 in “Scientific reports” Using gelatin sponges for deep skin wounds helps bone marrow cells repair tissue without scarring.
232 citations
,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
28 citations
,
February 2014 in “PLoS ONE” Epidermal stem cells on a special membrane helped mice regrow full skin with hair and functions.
1 citations
,
January 2016 in “Elsevier eBooks” The document concludes that a complete skin restoration biomaterial does not yet exist, and more clinical trials are needed to ensure these therapies are safe and effective.
November 2025 in “IECCMEXICO” 3D bioprinting advancements are improving skin regeneration for wound healing and personalized reconstruction.
September 2025 in “Drug Design Development and Therapy” Combining platelet-rich products, biomaterials, and bioactive substances may improve skin treatment, but more research is needed.
8 citations
,
January 2020 in “Biomaterials Science” Researchers developed a scaffold that releases a healing drug over time, improving wound healing and skin regeneration.
408 citations
,
January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
202 citations
,
August 2007 in “Biomaterials” Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.
163 citations
,
April 2019 in “Nature Communications” Mechanical stretching of the skin can promote hair growth by activating certain immune cells.
135 citations
,
December 2015 in “Expert Opinion on Biological Therapy” Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.
66 citations
,
August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
60 citations
,
November 2013 in “Development” Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.
56 citations
,
May 2017 in “Nature Cell Biology” Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
53 citations
,
April 2021 in “Cell Host & Microbe” Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.