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GlossaryDermal Papilla-Like Cells

lab-grown cells mimicking natural dermal papilla cells for hair growth

Dermal Papilla-Like Cells (DPLCs) are lab-grown cells that mimic the properties and functions of natural dermal papilla cells, which are found at the base of hair follicles and play a crucial role in hair growth and regeneration. These cells are often used in research and therapeutic applications to study hair loss conditions like alopecia and to develop potential treatments for promoting hair regrowth.

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Trajectory of Human Induced Pluripotent Stem Cells Derived Neural Progenitor Cells Differentiation into Dermal Papilla-Like Cells and Their Characteristics

research Trajectory of hiPSCs derived neural progenitor cells differentiation into dermal papilla-like cells and their characteristics

August 2023 in “Scientific reports”

Human stem cells were turned into cells similar to those that help grow hair and showed potential for hair follicle formation.

research Hair multiplication with dermal papilla like tissue containing human dermal papilla cells

June 2014 in “Biotechnology and Bioprocess Engineering”

Injecting lab-grown hair cells into the scalp can regrow hair.

Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

research Dermal Papilla Cells Improve the Wound Healing Process and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

68 citations , August 2014 in “Stem Cells Translational Medicine”

Dermal papilla cells help wounds heal better and can potentially grow new hair.

research Optimization of the reconstruction of dermal papilla like tissues employing umbilical cord mesenchymal stem cells

6 citations , February 2010 in “Biotechnology and bioprocess engineering”

Using umbilical cord stem cells can help create hair-growing tissues more affordably.

research Hair Growth Promoting Effect of Dermal Papilla Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells in Athymic Nude Mice

January 2016

Tissue from dog stem cells helped grow hair in mice.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

10 citations , January 2014 in “BioMed research international”

Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.

Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells Through Vascular Endothelial Growth Factor

research Hair growth promoting effect of dermal papilla like tissues from canine adipose-derived mesenchymal stem cells through vascular endothelial growth factor

8 citations , January 2016 in “Journal of Veterinary Medical Science”

Lab-made tissues from dog fat stem cells can help grow hair by releasing a growth factor.

Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis

research Extracellular vesicles from 3D cultured dermal papilla cells improve wound healing via Krüppel-like factor 4/vascular endothelial growth factor A -driven angiogenesis

1 citations , January 2023 in “Burns and trauma”

Tiny particles from 3D-grown skin cells speed up wound healing by promoting blood vessel growth.

research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1

37 citations , June 1996 in “Journal of cellular physiology”

Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

research Induction of insulin‐like growth factor‐I by cepharanthine from dermal papilla cells: A novel potential pathway for hair growth stimulation

13 citations , October 2013 in “The Journal of Dermatology”

Cepharanthine may help hair growth by increasing IGF-I in scalp cells.

research Erythropoietin induces insulin-like growth factor-1 from three-dimensional culture of human dermal papilla cells

October 2012 in “Journal of Dermatological Science”

Erythropoietin can promote hair growth by increasing IGF-1 in hair cells.

research Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule

January 2025 in “Biochemical Pharmacology”

Peficitinib can turn human fibroblasts into cells that help grow hair.

Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles

research Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles

11 citations , September 2014 in “International Journal of Molecular Sciences”

Mycophenolate helps reverse hair loss effects caused by IFN-γ by activating a key hair growth pathway.

research Chemically induced transformation of human dermal fibroblasts to hair‐inducing dermal papilla‐like cells

8 citations , July 2019 in “Cell Proliferation”

Researchers found a way to turn skin cells into cells that can grow new hair.

Induction of Dermal Fibroblasts into Dermal Papilla Cell-Like Cells in Hydrogel Microcapsules for Enhanced Hair Follicle Regeneration

research Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration

4 citations , August 2020 in “Applied Materials Today”

Hydrogel microcapsules help create cells that boost hair growth.

research Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cells

21 citations , November 2015 in “Phytomedicine”

Glycyrrhizic acid may help reduce unwanted hair growth.

Exploration of Aloe Vera, Centella Asiatica, Green Tea, and Pueraria Mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through Beta-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells

research Exploration of Aloe vera, Centella asiatica, Green Tea, and Pueraria mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through β-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells

February 2025 in “Natural Product Communications”

Aloe vera, Centella asiatica, Green Tea, and Pueraria mirifica extracts together boost hair growth by enhancing stem cell properties.

research Direct Conversion of Human Fibroblasts into Hair-Inducing Dermal Papilla Cell-Like Cells by a Single Small Molecule

January 2024 in “SSRN Electronic Journal”

research effects Of Low-level Laser Therapy (lllt) On Dermal Papilla Cell Proliferation And Insulin-like Growth Factor-1 (igf-1) Secretion From Balding Hair Follicles : #lb12

April 2014

research Differentiation capacity of stromal fibroblast-like cells from human bone marrow, adipose tissue, hair follicle dermal papilla and derma

7 citations , February 2009 in “Cell and tissue biology”

Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

research Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells

42 citations , February 2017 in “Scientific Reports”

Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.

research Canine Adipose-Derived Stem Cell Aggregates as a Viable Substitute to Actual Canine Dermal Papillae

4 citations , May 2015 in “Macedonian Veterinary Review”

Canine stem cell aggregates can effectively replace natural dermal papillae for hair research.

research Rescuing key native traits in cultured dermal papilla cells for human hair regeneration

30 citations , November 2020 in “Journal of Advanced Research”

Conditioned medium from keratinocytes can improve hair growth potential in cultured dermal papilla cells.

research Effect of ethanol extract of plant mixture on hair regeneration in human dermal papilla cells and C57BL/6J mice

4 citations , December 2015 in “Journal of Medicinal Plants Research”

A plant mixture extract helped grow hair by boosting cell growth and growth factors while blocking a hair loss-related enzyme.

Low-Frequency Electromagnetic Fields Promote Hair Follicle Regeneration by Injecting a Mixture of Epidermal Stem Cells and Dermal Papilla Cells

research Low-frequency electromagnetic fields promote hair follicles regeneration by injection a mixture of epidermal stem cells and dermal papilla cells

2 citations , July 2020 in “Electromagnetic Biology and Medicine”

Low-frequency electromagnetic fields help regenerate hair follicles using a mix of skin cells.

Effect of Scenedesmus Deserticola JD052 Extracts on Hair Inductivity by Regulating the AKT and GSK3β/β-Catenin Signaling Pathways in Human Dermal Papilla Cells

research Effect of Scenedesmus deserticola JD052 Extracts on Hair Inductivity by Regulating the AKT and GSK3β/β-Catenin Signaling Pathways in Human Dermal Papilla Cells

February 2025 in “Applied Sciences”

Scenedesmus deserticola JD052 extracts may help hair growth and could be a natural treatment for hair loss.

research 918 Tissue engineered human hair follicles from genetically, environmentally and extrinsically reprogrammed dermal papilla cells

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers developed a method to grow human hair follicles using 3D-printed skin models and modified cells.

research Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/ ¥-Catenin Signaling Pathway

37 citations , November 2019 in “Journal of Microbiology and Biotechnology”

Loliolide can boost hair growth by activating specific cell pathways.