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    GlossaryPapillary Fibroblasts

    specialized skin cells aiding in structure and hair growth

    Papillary fibroblasts are specialized cells found in the upper layer of the dermis, known as the papillary dermis. These cells play a crucial role in producing and organizing the extracellular matrix, which provides structural support to the skin. They are also involved in wound healing and hair follicle development, making them essential for maintaining healthy skin and hair growth.

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      community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

      in Research/Science 3 days ago
      AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  733 upvotes 3 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Anyone read oral minoxidil's leaflet?

      in Minoxidil  4 upvotes 1 year ago
      Oral minoxidil is discussed, highlighting potential cardiovascular risks at high doses, but users note that lower doses commonly used for hair loss are generally considered safe. Monitoring by doctors is advised, and some users report taking it without issues, comparing its risks to those of common medications like ibuprofen.

      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

      in Research/Science  56 upvotes 1 week ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.