research Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo
Stem cell differentiation involves gradual chromatin changes and dynamic gene activity.
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420-450 / 1000+ resultsresearch In pemphigus, cell detachment, but not autoantibody binding, induces cell-wide, long-lasting transcriptomic and proteomic changes
Cell detachment, not autoantibody binding, causes major changes in pemphigus.
research 0873 Modeling junctional epidermolysis bullosa using tissue-engineered skin substitutes
Tissue-engineered skin substitutes can model junctional epidermolysis bullosa and may help develop gene therapy.
research Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis
Keeping β-catenin levels high in mammary cells disrupts their development and branching.
research The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function
Glucosylceramides are essential for healthy skin and proper wound healing.
research Decision letter: Hair follicle epidermal stem cells define a niche for tactile sensation
Hair follicle stem cells are crucial for touch sensation and proper nerve structure in mice.
research Case Report: Bi-allelic missense variant in the desmocollin 3 gene causes hypotrichosis and recurrent skin vesicles
A new genetic change in the DSC3 gene is linked to a rare condition causing hair loss and skin blisters in a child.
research β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny
β1 integrin is essential for the survival, growth, and movement of human epithelial progenitor cells.
research Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis
Hox proteins help maintain keratinocyte identity by regulating miRNA expression.
research Extracellular proteoglycan decorin maintains human hair follicle stem cells
Decorin helps keep hair follicle stem cells and may prevent age-related hair loss.
research Epidermal and hair follicle transglutaminases and crosslinking in skin
research In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments
Scientists successfully created mouse hair proteins in the lab, which are stable and similar to natural hair.
research Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis
A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.
research Disturbed Epidermal Structure in Mice with Temporally Controlled Fatp4 Deficiency
Fatp4 is crucial for healthy skin development and function.
research The Majority of Multipotent Epidermal Stem Cells Do Not Protect Their Genome by Asymmetrical Chromosome Segregation
Most hair follicle stem cells do not protect their DNA by dividing it unevenly.
research 588 Skin fibroblast heterogeneity and plasticity are determined by the local niche
Mouse skin fibroblasts vary in function and adaptability based on their environment.
research Structural Transition of Trichocyte Keratin Intermediate Filaments During Development in the Hair Follicle
research Cross-linked features of mouse pelage hair resistant to detergent extraction
Some mutant mice have hair with abnormal cross-linking, mainly in the cuticle, not affecting other hair parts.
research Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation
Desmoglein 4 is controlled by specific proteins that affect hair growth.
research KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent manner
Normal cells outcompete and remove mutant cells in the pancreas with the help of the EphA2 receptor.
research ADSCs inhibit photoaging‐ and photocarcinogenesis‐related inflammatory responses and extracellular matrix degradation
ADSCs help protect skin from UV damage and aging.
research Hardwiring Stem Cell Communication through Tissue Structure
The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.
research 877 Integration of magnetic tweezers and traction force microscopy for exploring the mechanobiology of keratinocyte cell-cell and cell-matrix anchoring junctions
The conclusion is that a new method combining magnetic tweezers and traction force microscopy may help understand skin cell interactions and diseases.
research 177 The Striatin-Interacting Phosphatase And Kinases complex is important for skin epidermal differentiation and barrier formation
The STRIPAK complex is crucial for skin cell organization and creating a functional skin barrier.
research Cell Movement in the Hair Follicle Dermis – More Than a Two-Way Street?
DS cells in hair follicles can help form and restore hair, especially in hair loss conditions.
research Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation
Prominin-1 expressing cells in the dermal papilla help regulate hair follicle size and communication but don't aid in skin repair.
research The Progress of Epidermal Stem Cell Research
Epidermal stem cells help renew skin and heal wounds, influenced by specific proteins and markers.
research Pan-tissue scaling of stiffness versus fibrillar collagen reflects contractility-driven strain that inhibits fibril degradation
Tissue stiffness is influenced by contractility, which suppresses collagen breakdown.
research Author response: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
Reducing PIEZO1 speeds up wound healing.
research 862 Defining the molecular signature of the hair follicle dermal sheath and its functional requirement for hair cycle progression during catagen
The hair follicle dermal sheath is essential for hair shedding and needs to communicate with the outer root sheath for normal hair growth cycles.