research 9 Role of 5α-reductase in health and disease
5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
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research Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition
Finasteride effectively blocks rat enzymes, but with varying methods and strength.
research Doxil (Caelyx): an exploratory study with pharmacokinetics in patients with hormone-refractory prostate cancer
Doxil showed some effectiveness against advanced prostate cancer but caused severe side effects at higher doses.
research Emerging medication for the treatment of male hypogonadism
New treatments for male hypogonadism are effective and should be personalized.
research Induction of dark keratinocytes by 12-O-tetradecanoyl-phorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency
TPA is about 50 times more effective at promoting tumors than MZ.
research Focus on Skin as a Possible Port of Entry for Solid Nanoparticles and the Toxicological Impact
Nanoparticles can enter the skin, potentially causing toxicity, especially in damaged skin.
research The control of hair growth: An overview
Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.
research Regulatory roles of androgens in cutaneous wound healing
Testosterone may slow down wound healing and increase inflammation.
research Skin Keratins
Keratins are important for skin cell health and their problems can cause diseases.
research Association of Benign Prostatic Hyperplasia with Male Pattern Baldness
Men with enlarged prostates often have more severe baldness.
research Decreased Androgen Receptor Gene Methylation in Premature Pubarche: A Novel Pathogenetic Mechanism?
Reduced AR gene methylation may cause early pubic hair growth in girls.
research Ginseng phytochemicals as therapeutics in oncology: Recent perspectives
Ginseng may help treat cancer and reduce treatment side effects, but more research is needed.
research The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia
Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.
research A discourse on human hair fibers and reflections on the conservation of drug molecules
Hair analysis for drugs needs a better understanding of how drugs enter hair, considering factors like hair structure and pigmentation.
research Which chemicals should be grouped together for mixture risk assessments of male reproductive disorders?
Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.
research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin
Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.
research Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque.
Finasteride and minoxidil together promote hair growth better than either alone.
research Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers
Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.
research Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism.
Finasteride reduces hair growth and is safe for women with excessive hair.
research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach
Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.
research Unchanged androgen-binding properties of sex hormone-binding globulin in male patients with liver cirrhosis
SHBG binding properties are unchanged in male liver cirrhosis patients.
research Experimental and thermodynamic analyses of supercritical CO2-Solubility of minoxidil as an antihypertensive drug
Minoxidil dissolves better in propylene glycol + water than in supercritical CO2.
research The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen
Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.
research Hormonal activity in commonly used Black hair care products: evaluating hormone disruption as a plausible contribution to health disparities
Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.
research Improvement in Androgenetic Alopecia (Stage V) Using Topical Minoxidil in a Retinoid Vehicle and Oral Finasteride
Combination therapy improves hair growth in advanced hair loss.
research Topical absorption and systemic toxicity
Some chemicals absorbed through the skin can cause serious health problems.
research Recent discoveries and developments of androgen receptor based therapy for prostate cancer
New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.
research Female Pattern Hair Loss
Female pattern hair loss treatments vary in effectiveness and may have side effects.
research Emulgel: A Novel Approach For Hydrophobic Drugs
Emulgels effectively deliver hydrophobic drugs for skin conditions like acne and psoriasis.
research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1
A new compound effectively inhibits human 5α-reductase 1.