research Phytochemicals as Modulators of Human Endocrine Function: Bridging Traditional Remedies and Hormonal Health
Phytochemicals from plants may help improve hormonal health naturally.
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research Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair
PDCD4 is important for controlling skin cell growth and healing.
research Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone
New testosterone analogs show promise for male contraception with better activity and potentially fewer side effects.
research Synthesis and biological evaluation of dimeric peptide derivatives as proliferation‐stimulating agents in human follicle dermal papilla cells
Dimeric peptide derivatives could help hair growth and treat hair loss safely.
research Pharmacological Activity and Clinical Use of PDRN
PDRN helps repair tissue and improve wound healing with a high safety profile.
research A Dissolution Test for Finasteride in Immediate-Release Capsules
A method was developed to test the breakdown of Finasteride capsules, showing it can tell the difference between different brands and highlighting the need for standard tests and ingredient consistency.
research Erosive pustular dermatosis of the scalp: challenges and solutions
Early treatment of EPDS can improve outcomes and reduce recurrence risk.
research Dandelion-Derived Carbon Dots with pH-Responsive Charge and Dual ROS Regulation for Anti-Infection and Accelerated Wound Repair
Dandelion herb-derived carbon dots (DH-CDs) have been developed as a biocompatible antimicrobial agent with potential for wound healing. These nanoparticles exhibit broad-spectrum antibacterial activity against S. aureus and E. coli, with minimum inhibitory concentrations of 62.5 μg/mL at pH 7.4 and 31.25 μg/mL at pH 5.5. They disrupt bacterial membranes, inhibit energy metabolism, generate intracellular ROS, and inactivate antioxidant enzymes. DH-CDs can completely disrupt mature S. aureus biofilms at 300 μg/mL and show excellent biocompatibility, with a 10% hemolysis concentration exceeding 4000 μg/mL and over 95% viability of NIH 3T3 fibroblasts at 2000 μg/mL. They uniquely modulate ROS, eradicating bacteria while preserving mammalian cell redox homeostasis. In vivo, DH-CDs significantly accelerate wound healing in a murine model by promoting re-epithelialization, granulation tissue maturation, collagen deposition, and hair follicle regeneration, outperforming commercial wound healing sprays. These findings suggest DH-CDs as a promising candidate for treating bacteria-infected wounds.
research Epidermal growth factor, innovation and safety
Recombinant human epidermal growth factor is versatile, effective, and safe for long-term skin and mucosal treatments.
research A study of etretinate alopecia
Etretinate treatment changed hair growth patterns in many patients.
research Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair
Pluronic F127-derived hydrogels show promise for effective wound healing and repair.
research Noyes-Whitney Dissolution Model-Based pH-Sensitive Slow Release of Paclitaxel (Taxol) from Human Hair-Derived Keratin Microparticle Carriers
Human hair-derived particles can effectively carry and release the cancer drug Paclitaxel in a pH-sensitive manner, potentially targeting cancer cells while sparing healthy ones.
research Assessment of Circulating Sex Steroid Levels in Prepubertal and Pubertal Boys and Girls by a Novel Ultrasensitive Gas Chromatography-Tandem Mass Spectrometry Method
Prepubertal girls have higher sex steroid levels than boys, possibly leading to earlier puberty.
research Human Epidermal Transglutaminase
The enzyme is crucial for skin cell development and can be activated without proteolytic activation.
research The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs
The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.
research MLPH-mediated activation of dermal papilla IGF-1 signaling drives human hair shaft elongation and anagen induction
MLPH helps hair grow by activating IGF-1 signaling in hair cells.
research 28‐Day Repeated Dose Toxicity and Toxicokinetics Study on Dihydroartemisinin (DHA) in SD Rats
High doses of dihydroartemisinin caused reversible liver toxicity in rats, with females more affected than males.
research The anxiolytic-like effects of estazolam on a PTSD animal model
Estazolam reduces anxiety-like behavior in PTSD by increasing allopregnanolone levels.
research Improvement in physicochemical parameters of DPPC liposomes and increase in skin permeation of aciclovir and minoxidil by the addition of cationic polymers
Cationic polymers improved liposome stability and increased skin absorption of aciclovir and minoxidil.
research Genotype-phenotype correlation in boys with X-linked hypohidrotic ectodermal dysplasia
Boys with less severe EDA mutations in XLHED have milder symptoms and better sweat and hair production.
research INTRODUCING ELECTROMAGNETIC ENERGY FROM HYDROCOLLOID WOUND DRESSING PASTE PENETRATING A GLASS BARRIER DISRUPTING HUMAN SKIN LIPID DROPLETS SIZE AND MEMBRANES: POSSIBLE IMPLICATIONS IN CANCER CELLS GENESIS AND/OR CURE
Electromagnetic energy from wound dressing paste can disrupt skin lipid droplets, possibly affecting cancer development.
research Emulgel: A Novel Approach For Hydrophobic Drugs
Emulgels effectively deliver hydrophobic drugs for skin conditions like acne and psoriasis.
research A new START
PDF2 senses specific lipids and regulates root growth and gene expression in Arabidopsis.
research Experimental, molecular docking investigations and bioavailability study on the inclusion complexes of finasteride and cyclodextrins
Combining finasteride with dimethyl-β-cyclodextrin improves its absorption and bioavailability.
research Morphological analysis of polymers on hair fibers by SEM and AFM
Polyquaternium 7® builds up on hair, improving its look and feel, and AFM is good for measuring these changes.
research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase
New compounds were made that block an enzyme linked to breast cancer better than existing treatments.
research Efficacy and tolerance of 2,3-diphenylcyclopropenone in propylene glycol versus 2,3-diphenylcyclopropenone in isopropanol – a novel formula designed for the treatment of alopecia areata
Both treatments helped hair regrowth in alopecia areata, with isopropanol being better tolerated.
research An Adult With Hair Loss! a Rare Case of Non-Classical 3β Hydroxysteroid Dehydrogenase (3β HSD) Deficiency
A woman's hair loss and other symptoms were due to a rare hormone deficiency treatable with steroids.
research Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes
Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, and antioxidants may help treat hair loss.
research DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions
DHT deficiency can disrupt cell connections in rat testes, possibly affecting fertility.