Search

for
Search:

Did you mean Differentially Expressed Genes?

GlossaryDifferentially Expressed Genes

genes showing varied activity levels under different conditions

Differentially Expressed Genes (DEGs) are genes that show different levels of expression in different conditions, such as between healthy and diseased tissues. For example, in the context of alopecia, DEGs might be identified by comparing gene activity in hair follicles from individuals with alopecia to those without, helping researchers understand the molecular mechanisms underlying the condition.

Related Terms

Sort by

Research

30 / 1000+ results

research 139 Identification of long noncoding RNAs in mouse hair follicle stem cells using computational methods

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists found new and known long non-coding RNAs in mouse hair follicle stem cells that may be important for stem cell function and could be targets for cancer treatment.

research H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development

1 citations , August 2025 in “Epigenetics & Chromatin”

H3K4me3 helps control RSPO3 to influence hair growth and development.

Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

research Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms

3 citations , May 2023 in “Precision clinical medicine”

Researchers found four genes that could help diagnose severe alopecia areata early.

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.

Morpho-Regulation in Diverse Chicken Feather Formation: Integrating Branching Modules and Sex Hormone-Dependent Morpho-Regulatory Modules

research Morpho‐regulation in diverse chicken feather formation: Integrating branching modules and sex hormone‐dependent morpho‐regulatory modules

13 citations , December 2018 in “Development, Growth & Differentiation”

Sex hormones, especially estradiol, can change chicken feather shapes and colors.

research Molecular Basis of Maintaining Circannual Rhythm in the Skin of Cashmere Goat

1 citations , April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Goat skin changes with the seasons due to genes affected by daylight and hormones.

research Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis

July 2025 in “Genome biology”

HT-scCAT-seq helps understand gene regulation in embryonic skin development.

research Integrated Analysis of Methylome and Transcriptome Changes Reveals the Underlying Regulatory Signatures Driving Curly Wool Transformation in Chinese Zhongwei Goats

39 citations , January 2020 in “Frontiers in Genetics”

PDGFC gene may help select goats with desirable curly wool traits.

research Novel Insights to Assess Climate Resilience in Goats Using a Holistic Approach of Skin-Based Advanced NGS Technologies

June 2023 in “International journal of molecular sciences”

Heat stress changes goats' skin and hair at the microscopic level and affects their genes and skin bacteria.

research Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles

4 citations , November 2020 in “BMC Dermatology”

Researchers identified genes in scalp hair follicles that may affect hair traits and hair loss.

research EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

354 citations , February 2011 in “Genes & Development”

EZH1 and EZH2 are crucial for healthy hair growth and skin repair.

research Mettl3-catalyzed m ⁶ A regulates histone modifier and modification expression in self-renewing somatic tissue

24 citations , September 2023 in “Science Advances”

Mettl3 is essential for normal tissue development and self-renewal by regulating gene expression.

research Role of Sulfur Metabolism Gene and High-Sulfur Gene Expression in Wool Growth Regulation in the Cashmere Goat

1 citations , August 2021 in “Frontiers in Genetics”

Certain genes related to sulfur metabolism are more active during the growth phase of Cashmere goat wool, and melatonin might help this process.

research Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

research Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

24 citations , April 2020 in “Cells”

DNA methylation and long non-coding RNAs are key in controlling hair growth in Cashmere goats.

research Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients

48 citations , June 2014 in “Neurobiology of Disease”

The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.

research An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin

173 citations , August 2015 in “Developmental cell”

The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.

research Unlocking the genetic secrets of Dorper sheep: insights into wool shedding and hair follicle development

December 2024 in “Frontiers in Veterinary Science”

Dorper sheep's wool shedding is linked to specific genes and pathways, which may help understand human hair growth.

research 863 Molecular basis of hair follicle donor dominance in androgenetic alopecia and sexual dimorphism of the skin

April 2017 in “Journal of Investigative Dermatology”

Hair loss patterns differ between males and females due to 5 master regulators and JAK-STAT signaling affects hair growth.

research MOF-mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions By Controlling Gene Promoters

November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

MOF controls skin development by regulating genes for mitochondria and cilia.

research Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.

Thyroid Hormones and Androgens Differentially Regulate Gene Expression in Testes and Ovaries of Sexually Mature Silurana Tropicalis

research Thyroid hormones and androgens differentially regulate gene expression in testes and ovaries of sexually mature Silurana tropicalis

13 citations , July 2018 in “General and comparative endocrinology”

Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.

research Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts

24 citations , March 2021 in “Frontiers in Cell and Developmental Biology”

Wnt signaling is disrupted in asthma, affecting cell growth and inflammation.

research Role of EZH2 in Uterine Gland Development

6 citations , December 2022 in “International Journal of Molecular Sciences”

EZH2 is crucial for uterine gland development and female fertility.

research Genetic and molecular aspects of androgenetic alopecia

24 citations , January 2018 in “Indian Journal of Dermatology, Venereology and Leprology”

Androgenetic alopecia is mainly caused by genetic factors and increased androgen activity, leading to hair follicle miniaturization.

research Thyroxine Differentially Modulates the Peripheral Clock: Lessons from the Human Hair Follicle

30 citations , March 2015 in “PLoS ONE”

Thyroxine can adjust the body's peripheral clock, potentially helping treat clock-related diseases.

Catalytic-Dependent and -Independent Activities of Polycomb Repressive Complex 1 Differentially Regulate Skin Stem Cell Specification

research 864 Catalytic-dependent and -independent activities of Polycomb repressive complex 1 differentially regulate skin stem cell specification

April 2017 in “Journal of Investigative Dermatology”

PRC1 influences skin stem cell development by both turning genes on and off, affecting hair growth and skin cell types.

research Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness

24 citations , April 2017 in “Oncology Reports”

The hair keratin gene KRT81 is found in both normal and breast cancer cells and helps them invade surrounding tissues.

research Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages

71 citations , June 2005 in “Journal of Investigative Dermatology”

PAD enzymes play a key role in hair growth and structure.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

The Hairless gene is crucial for healthy skin and hair growth.