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240-270 / 1000+ resultsresearch La voie de la PGI2 pour améliorer la cicatrisation des plaies du pied diabétique
This study explored the role of the PGI2 pathway in diabetic foot ulcers (DFUs) using diabetic mouse models, a three-dimensional cellular model, and clinical studies. The research aimed to understand the alterations in the PGI2 pathway, which is crucial for vascular homeostasis and tissue repair. The study employed three techniques: in vivo skin microvascular reactivity assays, direct activation of PGI2 receptors, and analysis of gene and protein expression. The findings indicated changes in the PGI2 pathway in diabetic mice, particularly in gene and protein expression, but did not show dysfunction in the PGI2-dependent vasomotor effect. The study suggested that targeting the PGI2 pathway could be a potential therapeutic approach for DFUs.
research Structural & functional studies of L-PGDS and SMPDL3A enzymes in lipid signaling family
L-PGDS has specific binding sites for its functions and could help in drug delivery system design.
research Rapid generation of homogenous tumor spheroid microtissues in a scaffold-free platform for high-throughput screening of a novel combination nanomedicine
A new triple drug system using nanoparticles effectively targets breast tumors in 3D models.
research Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity
Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.
research Les cançons de l'escarni
Agaricus bisporus β-Glucan particles could effectively treat cervical cancer and offer antimicrobial and antioxidant benefits.
research Total Synthesis of Calanthoside, a Potential Hair Growth Stimulant: A Facile Synthetic Approach via One-Pot S- and O-Glucosidic Bond Formation
Calanthoside, a potential hair growth stimulant, was successfully synthesized using a new, efficient method.
research Gynostemma pentaphyllum Makino extract induces hair growth and exhibits an anti‐graying effect via multiple mechanisms
Gynostemma pentaphyllum extract may help grow hair and prevent graying.
research Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo
Plant-derived nanoparticles from Polygoni Multiflori Radix promote hair growth better than Minoxidil by affecting androgen pathways.
research Oral Administration of TrkB Agonist, 7, 8–Dihydroxyflavone Regenerates Hair Cells and Restores Function after Gentamicin–Induced Vestibular Injury in Guinea Pig
research Discovery and Optimization of Novel Pyridines as Highly Potent and Selective Glycogen Synthase Kinase 3 Inhibitors
New pyridine compounds effectively inhibit GSK3, a diabetes treatment target.
research Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis
DHT inhibition may increase spinal bone growth in ankylosing spondylitis.
research An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing
The injectable hydrogel effectively speeds up chronic wound healing.
research 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors
The document's conclusion cannot be provided because the document is not available or cannot be read.
research Suppression of spermatogenesis with desogestrel and testosterone pellets is not enhanced by addition of finasteride.
research The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression
The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.
research Flurandrenolide
research Ginsenosides in <i>Panax ginseng</i> Extract Promote Anagen Transition by Suppressing BMP4 Expression and Promote Human Hair Growth by Stimulating Follicle-Cell Proliferation
Panax ginseng extract helps human hair grow by encouraging growth phase transition and cell proliferation while reducing certain protein expression.
research Induction of Vascular Endothelial Growth Factor Messenger Ribonucleic Acid Expression in Stored Micrografts by Aminoguanidine
Aminoguanidine increases VEGF in stored hair micrografts, potentially improving their viability after transplant.
research Accelerated Wound Healing Using Nanoparticles
Nanoparticles can speed up wound healing and deliver drugs effectively but may have potential toxicity risks.
research Bletilla striata polysaccharide (BSP) promotes hair growth and suppresses oxidative stress and senescence of dermal papilla cells by inhibiting prostaglandin-endoperoxide synthase 2 (PTGS2)
research 560 The molecular mechanism of PCE-DP, a novel brightening active ingredient
PCE-DP brightens skin and promotes hair growth by enhancing cell growth and reducing melanin uptake.
research Novel type 1 5a-reductase Inhibitors with Antiproliferative Potential on LNCaP cells
New compounds may help treat prostate cancer by reducing cell growth.
research Diphencyprone Induced Vitiligo: A Case Report
Diphencyprone can cause unexpected and possibly permanent vitiligo.