2 citations
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October 2016 in “Nutrition in clinical practice” Vitamin B12 deficiency can cause facial dark spots that go away with treatment.
17 citations
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April 2002 in “Contact Dermatitis” Minoxidil 5% caused skin discoloration in a man using it for hair loss.
4 citations
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July 2019 in “Clinics in Dermatology” The document concludes that while white skin, nail, and mucosa diseases increase skin cancer risk, they are generally harmless, especially compared to darker pigmentation conditions.
32 citations
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May 2023 in “Preprints.org” Skin pigmentation varies due to genetics, UV exposure, and medications, with treatments available but requiring medical advice.
March 2026 in “European Journal of Biomedical and Life Sciences” Restorative dermopigmentation improves skin appearance and function by addressing specific skin issues.
March 2024 in “Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān/Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān./Zahedan journal of researches in medical sciences” Microneedling with PRP effectively reduces facial pigmentation with minimal side effects.
9 citations
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November 2015 in “JAMA dermatology” A 91-year-old woman's hair turned black in one spot, with skin changes underneath.
October 2019 in “European Journal of Dermatology” The boy's hair and skin color differences are due to a pigmentation disorder.
13 citations
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January 2009 in “The Open Dermatology Journal” Oral pigmentation can be a sign of Addison's disease.
1 citations
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July 2015 in “British Journal of Dermatology” Imiquimod improved skin pigmentation in most patients with xeroderma pigmentosum and may prevent further skin cancer, but some treatments can have side effects.
August 2024 in “Journal of the American Academy of Dermatology” Nail color change might be an early sign of skin pigmentation from minocycline.
July 1996 in “Hair transplant forum international” Using tretinoin and hydroquinone can speed up the fading of skin pigmentation.
October 2019 in “International journal of research in dermatology” Misusing topical corticosteroids can cause skin darkening and other side effects.
April 2018 in “Journal of Investigative Dermatology” The research found that a specific skin cell type not only triggers hair growth but also controls hair color, and that aging can lead to hair loss and color changes.
60 citations
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October 2010 in “Molecular Imaging and Biology” Increased skin pigmentation in mice reduces bioluminescent signal accuracy.
January 2023 in “Indian Dermatology Online Journal” Micropigmentation is a cosmetic tattooing technique for hiding skin issues and creating permanent makeup, but it can have side effects.
84 citations
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April 2005 in “Dermatologic Clinics” Treatments for melanin disorders exist, but more effective options needed.
60 citations
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January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Applying a specific inhibitor lightens skin and hair color.
PmtHEE is a better model for studying pigmented skin because it includes melanocytes and shows improved cell differentiation.
March 2025 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” Facial hyperpigmentation improved with oral isotretinoin and ivermectin cream after Demodex mites were identified as the cause.
7 citations
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March 1990 in “Pigment Cell Research” Certain chemicals cause hair graying in black mice but not yellow mice.
31 citations
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February 1999 in “Dermatologic surgery” Sun exposure after laser hair removal can cause skin darkening, which is hard to treat and requires avoiding UV light.
9 citations
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November 2017 in “Journal of Glaucoma” Latanoprost eye drops may cause skin depigmentation.
2 citations
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January 2002 in “Clinics in Dermatology” Vitiligo causes white skin patches, often starts before age 20, and is linked to other health issues.
2 citations
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May 2018 in “Dermatologic Surgery” Vitiligo is a chronic skin condition causing loss of color, linked to autoimmune issues.
12 citations
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January 2021 in “Dermatology Research and Practice” The 1927 nm Thulium laser effectively and safely treats postinflammatory hyperpigmentation in darker skin tones.
20 citations
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October 2018 in “American Journal of Clinical Dermatology” Some drugs can cause skin and hair color changes, often reversible when the drug is stopped.
June 2026 in “Dermatology and Therapy” Combining multiple ingredients is the most effective treatment for hyperpigmentation.
12 citations
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June 2010 in “Journal of dermatology” Some patients with severe alopecia areata developed skin darkening from their treatment, which may indicate a less effective response to the therapy.