research Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System
New skin disease treatments using TDDS are improving but face challenges like side effects and high costs.
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research Probing androgen receptor co-factor selectivity profiles: a chemical tool to determine cross-talk between androgen receptor and β-catenin in vivo
PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.
research Skin features in myotonic dystrophy type 1: An observational study
People with Myotonic Dystrophy type 1 are more likely to have certain skin conditions, but not more likely to get skin cancer.
research Mechanistic Insights on Dyspepsia Modulation by Salvia rosmarinus Through Network Pharmacology, Molecular Docking, and Molecular Dynamics
Rosemary may help reduce dyspepsia and gastric cancer risk.
research Pre-receptor regulation of the androgen receptor
Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.
research Gene detection in a family with monilethrix and treatment with 5% topical minoxidil
5% topical minoxidil improves hair density and quality in monilethrix patients.
research Mixed Connective Tissue Disease (MCTD) in a Girl with Lower Extremities Edema: A Brief Report
MCTD should be considered in children with recurring muscle issues, lupus-like symptoms, and edema.
research Dermoscopy: not just for dermatologists
Dermoscopy is useful for many health professionals, not just dermatologists, in improving skin condition diagnoses and reducing unnecessary biopsies.
research Comparative transcriptome profiling of hair follicles from forest musk deer (Moschus berezovskii) at different stages
The research provides insights into hair follicle growth in forest musk deer by identifying key genes and pathways involved.
research Identificación de la variación molecular y genética subyacente a las enfermedades de la piel
Non-coding RNAs may be key in diagnosing and treating rare skin disorders.
research The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin
S-Methylmethionine sulfonium can protect skin from UVB damage.
research LB920 Patient-reported side effects of oral minoxidil in treating female pattern hair-loss
Most women continued using oral minoxidil for hair loss despite mild to moderate side effects.
research Cancer vaccine strategies and studies of human thioredoxin reductase splice variants
Vaccines and targeting TrxR variants can help prevent cancer and reduce metastasis.
research A human vitamin D receptor mutation causes rickets and impaired Th1/Th17 responses
A vitamin D receptor mutation causes rickets and affects immune responses.
research Mobile phone app from NHS "hack day" is set to transform handovers and task lists
FFA can be mistaken for rosacea, requiring specific treatment for accurate diagnosis and management.
research Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK
Minoxidil prevents serotonin loss from MDMA by affecting potassium channels and increasing Akt phosphorylation.
research 554 Repurposing a clinical antimalarial for the therapeutic induction of lethal ER stress targeting BRAF-kinase inhibitor-resistant malignant melanoma
Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.
research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines
New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.
research Disorders of Sex Development
DSDs are birth conditions causing unusual sex development, managed with personalized care and sometimes surgery, but still lack a standard treatment approach.
research Scaled Quantum Chemical Studies of the Molecular Structure and Vibrational Spectra of Minoxidil
The analysis shows where minoxidil's atoms are likely to react and describes its electronic transitions and behavior with temperature changes.
research Therapeutic indications and other use-case-driven updates in the drug ontology: anti-malarials, anti-hypertensives, opioid analgesics, and a large term request
The Drug Ontology was updated to better classify drugs for hypertension, malaria, and opioid abuse, and to allow for more accurate research queries.
research 1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity
SCD1 inhibitors can cause skin issues in rodents.
research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration
Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.
research Antiviral drugs prolong survival in murine recessive dystrophic epidermolysis bullosa
Antiviral drugs, especially daclatasvir, may be a new treatment for a rare skin disease, improving survival and reducing symptoms in mice.
research The Dermatology Life Quality Index (DLQI ) used as the benchmark in validation of 101 quality‐of‐life instruments: A systematic review
The DLQI is a key tool for measuring quality of life in dermatology.
research Microneedles: A Promising Therapeutic Strategy for Next-Generation Drug Delivery, Diagnosis and Biosensing
Microneedles offer a painless, precise, and versatile method for drug delivery and disease treatment.
research Dysmorphic Concern Questionnaire: Greek Translation, Validation and Psychometric Properties
The Greek DCQ is a reliable and valid tool for assessing dysmorphic concern.
research A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing
The DiLiCre mouse model is an effective tool for precise genome editing using light.
research In vivo function of VDR in gene expression-VDR knock-out mice
Vitamin D receptor is crucial for bone health and mineral metabolism.
research COMPATIBILITY OF BIOMAGNETIC PROFILES FOUND IN LIVING MATTER BY CROSS SPECIES DEMONSTRATION
Hair follicles emit electromagnetic fields, useful for medical applications.