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GlossaryDNA Methyltransferase 1

maintains DNA methylation patterns during cell division

DNA Methyltransferase 1 (DNMT1) is an enzyme that plays a crucial role in maintaining DNA methylation patterns during cell division. It adds methyl groups to the cytosine bases of DNA, which can regulate gene expression by turning genes on or off. This process is essential for normal development, genomic stability, and cellular differentiation.

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Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

72 citations , July 2012 in “Journal of Investigative Dermatology”

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

research OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

57 citations , January 2019 in “Stem Cell Research & Therapy”

OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.

research DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo

20 citations , April 2019 in “BioMed Research International”

Treatments with sunscreen and active ingredients can reduce skin hyperpigmentation by decreasing DNA methylation.

research 1336 The de novo DNA methyltransferase DNMT3A is required for epidermal homeostasis

April 2018 in “Journal of Investigative Dermatology”

DNMT3A is crucial for healthy skin and hair growth.

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

1 citations , September 2012 in “Journal of Investigative Dermatology”

Aging reduces stem cell activation, leading to hair loss in mice lacking a specific enzyme.

H3K9me3 Methyltransferase SETDB1 Controls Retrotransposon Silencing, DNA Methylation, Constitutive Heterochromatin Maintenance and 3D-Chromatin Structure in Epidermal Keratinocytes

research 766 H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

Hypothalamic DNA Methylation in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome: Effects of Low-Frequency Electro-Acupuncture

research Hypothalamic DNA methylation in rats with dihydrotestosterone‐induced polycystic ovary syndrome: effects of low‐frequency electro‐acupuncture

18 citations , September 2018 in “Experimental physiology”

Electro-acupuncture may help treat PCOS in rats by changing brain DNA methylation.

research DNA Methylation as an Epigenetic Memory Keeper during Skin Development and Regeneration

1 citations , January 2018 in “Stem cell biology and regenerative medicine”

DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.

research Epigenetic control of adult stem cell function

179 citations , July 2016 in “Nature Reviews Molecular Cell Biology”

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

research Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice

6 citations , November 2022 in “Journal of Tissue Engineering and Regenerative Medicine”

Zebularine improved skin structure but delayed wound healing in diabetic mice.

research Epigenetic Modulation of ESR1 and DNMT3A Following Finasteride Exposure: Implications for Female Reproductive Function

May 2026 in “Physiology”

Finasteride may affect female fertility by altering gene activity.

research Acetate meliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation

1 citations , May 2022 in “Research Square (Research Square)”

Acetate helps reduce depression in rats with PCOS by lowering specific gene expression and DNA changes in the brain.

research The effect of DNMTs and MBPs on hypomethylation in systemic lupus erythematosus

6 citations , November 2008 in “Journal of Dermatological Science”

Certain proteins involved in DNA modification may affect the genetic changes in systemic lupus erythematosus and could indicate the disease's activity.

Standard DNA Methylation Analysis in Mouse Epidermis: Bisulfite Sequencing, Methylation-Specific PCR, and 5-Methyl-Cytosine Immunological Detection

research Standard DNA Methylation Analysis in Mouse Epidermis: Bisulfite Sequencing, Methylation-Specific PCR, and 5-Methyl-Cytosine (5mC) Immunological Detection

7 citations , October 2013 in “Methods in molecular biology”

These methods help understand DNA changes in mouse skin.

research DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging

December 2025 in “Clinical Cosmetic and Investigational Dermatology”

ZDHHC17 methylation may help treat or identify facial skin aging.

research High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders

15 citations , November 2022 in “Cell Death and Disease”

CEP135 may predict cancer outcomes, and targeting PLK1 could help treat certain sarcomas.

research Differentiation genes were governed by DNA methylation during hair follicle morphogenesis in Cashmere goat

January 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

DNA methylation controls hair follicle gene expression in cashmere goats.

research Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling

28 citations , August 2018 in “BMC genomics”

DNA methylation changes are linked to hair growth cycles in goats.

Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

research Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

24 citations , April 2020 in “Cells”

DNA methylation and long non-coding RNAs are key in controlling hair growth in Cashmere goats.

Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation-Related Enzyme, and Molecular Docking Studies

research Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation‐Related Enzyme, and Molecular Docking Studies

January 2025 in “BioMed Research International”

Targeting DNA methylation can help treat skin disorders and cancers.

research Epigenetic regulations on skin wound healing: implications from current researches.

5 citations , September 2015 in “PubMed”

Epigenetic changes are crucial for stem cell behavior in skin wound healing and their disruption may lead to cancer.

Beyond Goosebumps: Interactions Between the Hair Follicle, the Arrector Pili Muscle, and the Sympathetic Nerve During Development and Hair Follicle Regeneration

research 1334 Beyond goosebumps: Interactions between the hair follicle, the arrector pili muscle, and the sympathetic nerve during development and hair follicle regeneration

April 2018 in “Journal of Investigative Dermatology”

Arrector pili muscle regulates hair follicle stem cells, DNA methylation needed for hair cycling, and Wnt/B-catenin signaling starts hair growth.

research Epigenetic regulation in adult stem cells and cancers

20 citations , January 2013 in “Cell & Bioscience”

Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.

research Tailored chromatin modulation to promote tissue regeneration

10 citations , May 2019 in “Seminars in Cell & Developmental Biology”

Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

3 citations , January 2023 in “Science advances”

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

research PBX1-SIRT1 positive feedback loop attenuates ROS-mediated HF- MSC senescence and apoptosis

3 citations , April 2022 in “Research Square (Research Square)”

PBX1 reduces aging and cell death in stem cells by boosting SIRT1 and lowering PARP1.

research EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

354 citations , February 2011 in “Genes & Development”

EZH1 and EZH2 are crucial for healthy hair growth and skin repair.

Valproic Acid Reduces Hair Loss and Improves Survival in Patients Receiving Temozolomide-Based Radiation Therapy for High-Grade Glioma

research Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma

26 citations , November 2016 in “European Journal of Clinical Pharmacology”

Valproic acid helps delay hair loss and increases survival time for high-grade glioma patients undergoing radiation therapy.

Identifying Molecular Targets for Reverse Aging Using Integrated Network Analysis of Transcriptomic and Epigenomic Changes During Aging

research Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging

12 citations , June 2021 in “Scientific Reports”

Curcumin may help reverse aging by targeting specific genes.

Combined Oral Contraceptives Promote Androgen Receptor And Estrogen Receptor Alpha Upregulation In The Female Prostate (Skene’s Paraurethral Glands) Of Adult Gerbils (Meriones Unguiculatus)

research Combined oral contraceptives promote androgen receptor and oestrogen receptor alpha upregulation in the female prostate (Skene’s paraurethral glands) of adult gerbils (Meriones unguiculatus)

3 citations , January 2018 in “Reproduction, Fertility and Development”

Birth control pills increase certain receptor activities in female gerbil prostate glands and can lead to prostate changes.