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GlossaryTen-Eleven Translocation Methylcytosine Dioxygenase

enzyme that modifies DNA to regulate gene expression

Ten-Eleven Translocation Methylcytosine Dioxygenase, often abbreviated as TET, is an enzyme that plays a crucial role in DNA demethylation, a process that can activate or deactivate genes. TET enzymes modify methylated cytosines (a component of DNA) by converting them into hydroxymethylcytosines, which can then be further processed to remove the methyl group entirely. This activity is essential for regulating gene expression and maintaining normal cellular functions, and disruptions in TET function have been linked to various diseases, including cancer.

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DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation

3 citations , January 2023 in “Science advances”

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Keratinocyte Differentiation and Hair Growth

research 1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Tet2 and Tet3 enzymes are important for controlling hair growth and shape by affecting gene activity and DNA structure in hair follicles.

research 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) from Polygonum multiflorum Thunb.: A Systematic Review on Anti-Aging

3 citations , April 2025 in “International Journal of Molecular Sciences”

TSG from Polygonum multiflorum may help with anti-aging by protecting the brain, heart, bones, and hair.

DNA Methylation as an Epigenetic Memory Keeper During Skin Development and Regeneration

research DNA Methylation as an Epigenetic Memory Keeper during Skin Development and Regeneration

1 citations , January 2018 in “Stem cell biology and regenerative medicine”

DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.

Exploring Nanotechnology With Traditional Herbal Pharmacology: Nano Carrier-Based Phytochemical Delivery In PCOS Treatment

research Exploring Nanotechnology With Traditional Herbal Pharmacology: Nano Carrier-Based Phytochemical Delivery In PCOS Treatment

July 2025

Combining nanotechnology with herbal medicine may improve PCOS treatment.

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