Search

for
Search:

Sort by

Research

930-960 / 1000+ results

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Reply by the authors

September 2004 in “Urology”

Dutasteride may help prevent prostate cancer, but more research is needed.

research The Antiandrogens

19 citations , January 1993 in “Dermatologic Clinics”

5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

110 citations , August 2015 in “Neuropsychopharmacology”

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

research The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.

44 citations , May 1998 in “PubMed”

The retinoid receptor antagonist effectively disrupts vitamin A-related development in embryos.

research Slow progress in prostate cancer

February 2007 in “BJUI”

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

research BindingDB Entry 50021519: Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

January 2025

research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors

20 citations , March 2005 in “Current Medicinal Chemistry”

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

research Comparison of clinical trials with finasteride and dutasteride.

20 citations , January 2004 in “PubMed”

Dutasteride reduces DHT more than finasteride, but both drugs improve BPH symptoms similarly.

research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

45 citations , August 2005 in “Bioorganic & medicinal chemistry”

New compounds with carborane showed anti-androgen effects similar to flutamide.

research Metabolic effects of 5α-reductase inhibition in humans

July 2013 in “Edinburgh Research Archive (University of Edinburgh)”

Dutasteride may reduce insulin sensitivity and increase body fat.

research RE: EFFECT OF THE DUAL 5α-REDUCTASE INHIBITOR DUTASTERIDE ON MARKERS OF TUMOR REGRESSION IN PROSTATE CANCER

3 citations , March 2005 in “The Journal of urology/The journal of urology”

Dutasteride may help shrink prostate cancer tumors.

research α‐Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo‐prevention

9 citations , April 2006 in “International Journal of Dermatology”

DFMO may help control hair growth and treat cancer.

research The Shifting Landscape of Disease-Modifying Therapies for Relapsing Multiple Sclerosis

4 citations , May 2018 in “Journal of Neuro-Ophthalmology”

New treatments for relapsing multiple sclerosis are more effective and convenient but have higher risks of serious side effects.

Non-Steroidal Modulation of the 5-Alpha Reductase Axis: A Dual Therapeutic Strategy for Prostatic Chemoprevention and Androgenetic Alopecia

research Non-Steroidal Modulation of the 5-Alpha Reductase Axis: A Dual Therapeutic Strategy for Prostatic Chemoprevention and Androgenetic Alopecia

January 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

LX-38 is a safer drug option for treating prostate issues and hair loss without hormonal side effects.

research Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells

35 citations , April 2009 in “Journal of Neuroscience Research”

HDAC inhibitors help brain cells grow and improve brain function.

research SRD5A2 and emerging therapies in androgen-driven disorders

January 2026 in “Nature Reviews Urology”

research 2‐Deoxy‐d‐glucose enhances tonic inhibition through the neurosteroid‐mediated activation of extrasynaptic GABA_A receptors

44 citations , October 2016 in “Epilepsia”

2-DG reduces seizures by enhancing brain inhibition through specific receptor activation.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations , May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

research [Neurosteroidogenesis and exploratory responses in rodents].

1 citations , January 2014 in “PubMed”

Certain substances can decrease or increase exploratory behavior in rodents.

research Do Alpha-Blockers and 5-Alpha Reductase Inhibitors Increase Dementia Risk? A Network Meta-analysis

December 2025 in “International Neurourology Journal”

Alpha-blockers and 5-alpha reductase inhibitors don't significantly increase dementia risk.

research Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors

19 citations , March 2010 in “Steroids”

Certain progesterone derivatives can inhibit enzymes and reduce androgenic activity, potentially affecting prostate growth.

research Non-Steroidal Modulation of the 5-Alpha Reductase Axis: A Dual Therapeutic Strategy for Prostatic Chemoprevention and Androgenetic Alopecia

January 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

LX-38 is a safer drug option for hair loss and prostate issues without hormonal side effects.

Finasteride, a 5α-Reductase Inhibitor, Potentiates Antinociceptive Effects of Morphine, Prevents the Development of Morphine Tolerance and Attenuates Abstinence Behavior in the Rat

research Finasteride, a 5α-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat

15 citations , March 2007 in “Hormones and Behavior”

Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.

Luncheon Symposium: Update on the Efficacy and Safety of Dutasteride in the Management of Androgenetic Alopecia

research Luncheon Symposium (LS) : Update on the efficacy and safety of dutasteride in the management of androgenetic alopecia

January 2015 in “프로그램북(구 초록집)”

Dutasteride is effective and safe for treating common hair loss, and it's more potent than finasteride, leading to better hair growth and thickness.

research A Comparison of Varying alpha-Blockers and Other Pharmacotherapy Options for Lower Urinary Tract Symptoms.

52 citations , January 2005 in “PubMed”

Alpha-blockers are the most effective and widely used treatment for lower urinary tract symptoms, with minimal side effects.

research The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim

86 citations , July 1990 in “British Journal of Pharmacology”

Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.

research The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder

8 citations , April 2021 in “Journal of Clinical Investigation”

Finasteride reduces opioid use and withdrawal symptoms in animals.

research Computational Screening of Repurposed Drugs Targeting Sars-Cov-2 Main Protease By Molecular Docking

1 citations , September 2022 in “Sudan Journal of Medical Sciences”

Danoprevir, remdesivir, and saridegib may effectively inhibit SARS-CoV-2.

← Previous page Next page →