research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
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research Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats
Finasteride affects young male rats' brain function and behavior negatively.
research Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation
Finasteride may help improve certain brain function issues linked to dopamine.
research Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation
Blocking CYP17A1 enzyme may help improve certain brain function issues related to dopamine.
research Ejaculatory dysfunction in the treatment of lower urinary tract symptoms
Treatments for urinary symptoms often cause ejaculatory problems.
research The connection of 5-alpha reductase inhibitors to the development of depression
5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.
research Effect of 5-alpha reductase inhibitors in animal models of Parkinson’s disease
5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.
research The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson’s disease
Finasteride reduces movement issues in Parkinson's disease rats.
research The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation
The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.
research Is seborrhea a sign of autonomic impairment in Parkinson's disease?
Seborrhea in Parkinson's disease may be linked to hormones, not autonomic impairment.
research The Sodium Valproate: Doctor Jekyll and Mister Hyde
Sodium valproate is effective in treating epilepsy, especially in patients who don't respond to other medications.
research Neuroactive gonadal drugs for neuroprotection in male and female models of Parkinson's disease
Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.
research The 5α-reductase inhibitor Dutasteride but not Finasteride protects dopamine neurons in the MPTP mouse model of Parkinson’s disease
Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.
research The role of AUTS2 in neurodevelopment and human evolution
The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.
research Polycystic ovary syndrome and impact on health
PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.
research Levodopa-induced skin disorders in patients with Parkinson disease: a systematic literature review approach
Levodopa for Parkinson's disease might be linked to skin issues like melanoma, but it's unclear if the drug or the disease causes them.
research Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments
iPSCs help understand and treat neurodevelopmental disorders.
research NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
research Poster Abstracts
The model and estimator can predict drug exposure in kidney transplant patients well.
research Neurosteroids, neuroactive steroids, and symptoms of affective disorders
Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.
research Adverse effects of common medications on male fertility
Some common medications can harm male fertility, but many effects can be reversed.
research Does prolactin play a role in skin biology and pathology?
Prolactin may be important for skin growth and immune function.
research De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes
The research found genetic differences in identical twins that could explain why one twin has a disease while the other does not.
research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction
Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.
research Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models
Stress worsens Tourette symptoms by increasing allopregnanolone levels.
research Gilles de la Tourette syndrome – A treatable condition?
Gilles de la Tourette syndrome is treatable, with behavioral therapy as a recommended first option and other treatments available for more severe cases.
research Finasteride improves motor, EEG, and cellular changes in rat brain in thioacetamide-induced hepatic encephalopathy
Finasteride helps brain function in rats with liver-related brain issues.
research Trichotillomania
Trichotillomania, a disorder where people compulsively pull out their own hair, often starts around age 12, is more common in adult females, and can be treated with behavior therapy and medication.
research Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation
Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.
research Pediatric Bipolar Disorder: Evidence-Based Psychopharmacological Treatments
Combining mood stabilizers with antipsychotics is more effective for treating children with bipolar disorder than using mood stabilizers alone.