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GlossaryDorsal Root Ganglia

clusters of nerve cell bodies transmitting sensory information to the spinal cord

Dorsal Root Ganglia (DRG) are clusters of nerve cell bodies located along the spinal cord. They play a crucial role in transmitting sensory information from the peripheral nervous system to the central nervous system, including sensations like pain, temperature, and touch.

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Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

66 citations , July 2007 in “Journal of Molecular Medicine”

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

research Localization of mechanosensitive channel TRPV4 in mouse skin

123 citations , November 2003 in “Neuroscience Letters”

TRPV4 helps sense pressure in mouse skin.

research KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors

19 citations , February 2016 in “Journal of Biological Chemistry”

KCNQ potassium channels help control the sensitivity of touch receptors in the skin.

research Different Requirements for GFRα2-Signaling in Three Populations of Cutaneous Sensory Neurons

11 citations , August 2014 in “PLoS ONE”

GFRα2 is essential for controlling neuron size but not for target innervation in certain sensory neurons.

ELife Assessment: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research eLife assessment: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

February 2024

Meis2 is essential for touch sensation and proper nerve connection to touch receptors in certain skin areas of mice.

Local Injection With Anti-Herpes Simplex Virus Antibodies Protects Against Development of Herpes Simplex Virus-Induced Sweating Disturbance

research 1389 Local injection with anti-herpes simplex virus antibodies protects against development of herpes simplex virus–induced sweating disturbance

April 2023 in “Journal of Investigative Dermatology”

Injecting anti-herpes antibodies locally can prevent skin lesions and sweating problems caused by herpes simplex virus in mice.

research Tfap2b specifies an embryonic melanocyte stem cell that retains adult multi-fate potential

June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.

research In vitro interactions between sensory nerves, epidermis, hair follicles and capillaries in a tissue‐engineered reconstructed skin

September 2004 in “Experimental Dermatology”

The model effectively studies how sensory nerves interact with skin components, aiding research on wound healing and hair growth.

research Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae

32 citations , February 2024 in “Growth Hormone & IGF Research”

Dihydrotestosterone (DHT) stops hair growth in mice by lowering a growth factor important for hair.

Experimental Dataset for Hair Follicle Neural Crest Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration via miR-214-3p

research Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p

January 2026 in “Mendeley Data”

Hair follicle stem cell exosomes help nerve regeneration.

research Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p

January 2026 in “Mendeley Data”

Hair follicle stem cell exosomes help nerve regeneration.

research 329 In vitro co-culture models of merkel cell-neurite complex in touch domes

October 2021 in “Journal of Investigative Dermatology”

The study concluded that the developed models are effective for studying hair growth mechanisms and testing new treatments.

research Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice

29 citations , March 2011 in “The Journal of Nutritional Biochemistry”

Eating isoflavone can help mice grow hair by increasing a growth factor.

research Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number

34 citations , July 2006 in “The Journal of Comparative Neurology”

Increasing neurotrophin 4 in skin boosts nerve endings but not sensory neuron count.

research Epidermal Growth Factor Receptor Regulates Skin Nerve Outgrowth and Branching

February 2009 in “Journal of Investigative Dermatology”

EGFR is essential for organized skin nerve growth and branching.

Branching of Spiral Ganglion Neurites Induced by Focal Application of Fibroblast Growth Factor-1

research Branching of Spiral Ganglion Neurites Is Induced by Focal Application of Fibroblast Growth Factor‐1

15 citations , May 2003 in “The Laryngoscope”

FGF-1 causes spiral ganglion neurites to branch more.

research Responses of type II spiral ganglion neurites to stripes of laminin and fibronectin

January 2011

Type II spiral ganglion neurites avoid high concentrations of laminin and fibronectin.

Angelica Gigas Nakai (Korean Dang-Gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy: Active Phytochemicals and In Vivo Molecular Targets

research Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets

2 citations , January 2025 in “Pharmaceutical Research”

Angelica gigas Nakai root extracts may help with cancer, pain, memory loss, and metabolic issues.

research Lack of Evidence for Sprouting of Aβ Afferents into the Superficial Laminas of the Spinal Cord Dorsal Horn after Nerve Section

115 citations , October 2003 in “Journal of Neuroscience”

Aβ afferents do not sprout into the superficial spinal cord layers after nerve injury.

Correlation of Monosynaptic Field Potentials Evoked by Single Action Potentials in Single Primary Afferent Axons and Their Bouton Distributions in the Dorsal Horn

research Correlation of monosynaptic field potentials evoked by single action potentials in single primary afferent axons and their bouton distributions in the dorsal horn

21 citations , April 1990 in “Journal of comparative neurology”

The study found that nerve signals are stronger when there are more connection points, but not necessarily denser, along the nerve's path in the spine.

research Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells

March 2025 in “International Journal of Molecular Sciences”

The study created a mouse model to better understand hair follicle stem cells' role in hair growth and repair.

research 1369 Blue light stimulatory effect on hair growth mediated by opsin and cryptochrome photoreceptors

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blue light can help hair grow by affecting certain receptors in hair follicles.

research Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation

67 citations , December 2008 in “Developmental Biology”

Msx2 and Foxn1 are both crucial for hair growth and health.

research Hair growth promotion by Necrostatin-1s

12 citations , October 2020 in “Scientific Reports”

Necrostatin-1s can promote hair growth and may help treat hair loss.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)

6 citations , May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

140 citations , February 2014 in “Neuron”

Delta opioid receptors help regulate touch sensation by reducing neurotransmitter release in the spinal cord.

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research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

research Localization of mechanosensitive channel TRPV4 in mouse skin

research KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors

research Different Requirements for GFRα2-Signaling in Three Populations of Cutaneous Sensory Neurons

research eLife assessment: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

research 1389 Local injection with anti-herpes simplex virus antibodies protects against development of herpes simplex virus–induced sweating disturbance

research Tfap2b specifies an embryonic melanocyte stem cell that retains adult multi-fate potential

research In vitro interactions between sensory nerves, epidermis, hair follicles and capillaries in a tissue‐engineered reconstructed skin

research Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae

research Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p

research Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p

research 329 In vitro co-culture models of merkel cell-neurite complex in touch domes

research Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice

research Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number

research Epidermal Growth Factor Receptor Regulates Skin Nerve Outgrowth and Branching

research Branching of Spiral Ganglion Neurites Is Induced by Focal Application of Fibroblast Growth Factor‐1

research Responses of type II spiral ganglion neurites to stripes of laminin and fibronectin

research Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets

research Lack of Evidence for Sprouting of Aβ Afferents into the Superficial Laminas of the Spinal Cord Dorsal Horn after Nerve Section

research Correlation of monosynaptic field potentials evoked by single action potentials in single primary afferent axons and their bouton distributions in the dorsal horn

research Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells

research 1369 Blue light stimulatory effect on hair growth mediated by opsin and cryptochrome photoreceptors

research Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation

research Hair growth promotion by Necrostatin-1s

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)

research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

research The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

research The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles

research Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins

research The Effect of EGR1 on the Proliferation of Dermal Papilla Cells