Low-dose sorafenib can cause severe facial acne, treatable with topical medication.
December 2018 in “Progress in Medical Sciences” Low doses of date palm extract improve kidney function, but high doses can harm it.
October 2017 in “Universidad Nacional de Trujillo” Low doses of Coffea arabica seed extract prevent prostate growth and lower uric acid and PSA levels.
January 2010 in “Nonlinearity in Biology Toxicology Medicine” Low-dose effects in rodent studies are hard to confirm due to confounding factors and control group variability.
July 2009 in “Medical & surgical dermatology” Low-dose acitretin helps nail psoriasis, stem cells may treat scarring alopecia, Chinese men have lower baldness rates, lateral foldplasty is good for ingrown toenails, hair diameter helps diagnose female baldness, childhood trauma linked to alopecia areata, certain hair-weaving leads to scalp conditions in African American women, and new methods for hair research and understanding hair and sweat gland development were introduced.
March 2009 in “The Journal of Urology” Low dose finasteride causes only small changes in PSA levels in older men with BPH.
October 2007 in “Obstetrical & Gynecological Survey” Low-dose methotrexate, combined with surgical and local treatments, effectively treats severe vulvovaginal lichen planus.
September 2007 in “대한피부과학회지” High dose methylprednisolone effectively stops hair loss and promotes regrowth in acute diffuse alopecia areata.
November 2003 in “Aap Grand Rounds” Low-dose flutamide-metformin therapy effectively improved PCOS symptoms in adolescent girls.
January 1982 in “Side effects of drugs annual” High doses of certain vitamins can cause serious side effects and health risks.
May 2023 in “Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ” High doses of rosemary extract can harm the liver, kidneys, and reproductive organs in young rats.
January 2009 in “The Chinese Journal of Dermatovenereology” Higher doses of Tribulus terrestris extract increase MC-1R expression in mouse hair follicles.
Low doses of certain Chinese herbs can promote hair growth, while high doses may inhibit it.
Higher doses of prednisone and triamcinolone acetonide successfully treated 8 out of 10 alopecia totalis patients.
April 2023 in “Actas Dermo-Sifiliográficas” Low doses of oral minoxidil, a hair loss treatment, can cause temporary morning swelling around the eyes, but it's not serious and can disappear with continued use or dose adjustment.
June 2021 in “Current developments in nutrition” High doses of finasteride lower cholesterol and body weight in certain mice.
73 citations
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October 2001 in “Epilepsia” Children taking higher doses of valproic acid had lower biotinidase activity, which may lead to biotin deficiency, but biotin supplements could help.
37 citations
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February 2008 in “PubMed” Keeping radiation doses under 16 Gy may reduce permanent hair loss.
29 citations
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October 1996 in “Toxicology and Applied Pharmacology” Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.
21 citations
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December 1997 in “The Journal of Dermatology” Thymectomy and high-dose prednisolone improved hair loss in a woman with alopecia areata.
20 citations
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November 2015 in “International Journal of Gynecology & Obstetrics” Both contraceptive pill doses effectively reduced androgen levels in women with PCOS.
18 citations
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May 2014 in “Menopause” A 5 mg dose of transdermal testosterone cream effectively restores testosterone levels in postmenopausal women.
11 citations
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May 2000 in “International Journal of Dermatology” Taking a small dose of prednisone before menstruation can almost completely prevent premenstrual acne with few side effects.
9 citations
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October 2018 in “Journal of Cosmetic Dermatology” Isotretinoin at a low dose for three months does not significantly affect hair growth.
9 citations
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November 2017 in “Dermatologic Clinics” Men need higher doses of botox than women and a different approach for facial aesthetics due to their unique facial features and muscle mass.
9 citations
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January 2007 in “mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)” Microbeam radiation therapy's dose distribution changes with depth.
8 citations
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October 2017 in “Dermatologic Surgery” Men need higher doses and tailored injection techniques for botulinum toxin treatments due to their unique facial features.
5 citations
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June 2021 in “Journal of neurology, neurosurgery and psychiatry” Taking high doses of Cyproterone acetate significantly increases the risk of meningioma in females.
1 citations
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October 2023 in “Animals” A small dose of Platycladus orientalis leaf extract improves raccoon dogs' growth and health, but higher doses can be harmful.
1 citations
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August 2023 in “JAMA Dermatology” Increasing the dose of baricitinib to 4 mg helps more patients with severe alopecia areata regrow hair.