research Induction of ornithine decarboxylase activity in hairless rat epidermis as a pharmacological model: validation of the animal model
Female rats aged 8 weeks are best for this model.
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research 5-Alpha-reductase deficiency in a Saudi "girl"
A Saudi individual initially identified as a girl had a genetic disorder affecting gender development.
research 1103 Derinat extends hair cycle at anagen phase by decreasing the level of TRPCs-mediated intracellular ROS accumulation in skin
Derinat helps extend hair growth by reducing harmful molecules in skin cells.
research Revitalize DTC Hair Regrowth - The flip side of perfection
DTC hair regrowth solutions are improving hair health and confidence with innovative, personalized approaches.
research Drug-induced erectile dysfunction: a real-world pharmacovigilance study using the FDA adverse event reporting system database
Finasteride is most linked to drug-induced erectile dysfunction.
research Post-Drug Syndromes: A Neglected Challenge in Pharmacovigilance and Public Health
Current drug safety systems fail to detect long-term side effects, leading to preventable health issues.
research Reviving the Pulp with PRP: A New Era in Endodontic Regeneration
PRP shows promise for regenerating dental tissues.
research Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin
High levels of ODC and a mutant Ha-ras gene cause tumors in mice.
research Two New Unrelated Cases of Hereditary 1,25-Dihydroxyvitamin D-resistant Rickets with Alopecia resulting from the same Novel Nonsense Mutation in the Vitamin D Receptor Gene
A new gene mutation causes vitamin D resistance and hair loss in two unrelated girls.
research Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity
Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.
research A function for Rac1 in the terminal differentiation and pigmentation of hair
Rac1 is essential for proper hair structure and color.
research Editorial highlights
Recent advances show zebrafish can model anemia, Alx4 affects craniofacial and hair development, and mTORC1 is crucial for retinal development.
research 688 Precise and efficient editing of the COL7A1 gene in RDEB derived iPSCs with CRISPR/Cas9 and prime editing
CRISPR/Cas9 and prime editing can potentially fix skin disorder genes safely and effectively.
research DecisionDx‐Melanoma and Sentinel Lymph Node Biopsy
research Exogenous calreticulin improves diabetic wound healing
Applying calreticulin can speed up wound healing in diabetics.
research Alcohol Exposure During Late Adolescence Increases Drinking in Adult Wistar Rats, an Effect that is not Reduced by Finasteride
Alcohol in teen years leads to more adult drinking, finasteride doesn't help.
research Vitamin D and the skin: Physiology and pathophysiology
Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.
research Interactions of the Vitamin D Receptor with the Corepressor Hairless
Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.
research Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type
Retinoic acid can either maintain stem cells or make them specialize, depending on the cell type.
research The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?
The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.
research Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation
Vitamin D receptor helps control skin cell growth and hair development.
research (291) The Effect of Administration and Discontinuation of Finasteride in Male Rats
Finasteride's negative effects on brain tissue in male rats may be reversible after stopping the drug.
research Synergistic effect of carbodiimide and dehydrothermal crosslinking on acellular dermal matrix
Combining DHT and EDC improves the strength and stability of PADM scaffolds for tissue engineering.
research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways
Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.
research Effects of dobutamine on cyclic AMP accumulation induced by the stimulation of dopamine receptors in rabbit retina in vitro
Dobutamine does not mimic dopamine at therapeutic doses but may at very high concentrations; microfilaments, not microtubules, are important for wound healing in Xenopus embryos.
research 28‐Day Repeated Dose Toxicity and Toxicokinetics Study on Dihydroartemisinin (DHA) in SD Rats
High doses of dihydroartemisinin caused reversible liver toxicity in rats, with females more affected than males.
research A DEEP LEARNING APPROACH FOR DIAGNOSIS OF COVID-19 INFECTION AND ITS RELATED FACTORS: A POPULATION-BASED STUDY
The random forest model effectively helps diagnose COVID-19 using key factors like age and symptoms.
research Identification of key genes in type 2 diabetes‐induced erectile dysfunction rats with stem cell therapy through high‐throughput sequencing and bioinformatic analysis
Stem cell therapy affects 15 key genes in rats with diabetes-related erectile dysfunction.
research 697 Prostaglandin D2-enhanced testosterone metabolism in human keratinocytes is mediated by reactive oxygen species
Prostaglandin D2 increases testosterone levels in skin cells through reactive oxygen species, not enzymes, which could lead to new hair loss treatments.
research Molecular docking of Vitamin D3 Receptor (VDR) with potential herbal substance as ligand to prevent excessive hair loss in menopausal women
Certain herbal compounds might help prevent hair loss in menopausal women by activating Vitamin D receptors.