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GlossaryDutasteride

medication that inhibits DHT to treat enlarged prostate and hair loss

Dutasteride, also known by the brand name Avodart, is a medication primarily used to treat benign prostatic hyperplasia (BPH), which is an enlarged prostate. It works by inhibiting the action of the enzyme 5-alpha-reductase, which converts testosterone to dihydrotestosterone (DHT), a hormone that contributes to prostate growth. Additionally, dutasteride is sometimes used off-label to treat male pattern baldness due to its ability to reduce DHT levels, which are implicated in hair loss.

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Developing and Validating an HPLC Method to Quantify Simultaneously Dutasteride and Their Related Molecules (Dutasteride Acid, 2,5 Bis-(Trifluoromethyl)-Aniline and Dutasteride 17 α-Epimer) in Capsules

research DEVELOPING AND VALIDATING AN HPLC METHOD TO QUANTIFY SIMULTANEOUSLY DUTASTERIDE AND THEIR RELATED MOLECULES (DUTASTERIDE ACID, 2,5 BIS- (TRI FLUORO METHYL)-ANILINE AND DUTASTERIDE 17 α-EPIMER) IN CAPSULES

January 2020 in “International Journal of Research in Pharmacy and Chemistry”

A reliable method was created to measure dutasteride and related molecules in capsules.

Preparation and Characterization of Dutasteride-Loaded Nanostructured Lipid Carriers Coated with Stearic Acid-Chitosan Oligomer for Topical Delivery

research Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery

47 citations , April 2017 in “European Journal of Pharmaceutics and Biopharmaceutics”

The new dutasteride formula can be applied to the skin, may promote hair growth, and has fewer side effects.

research In Vitro Performance of Dutasteride-Nanostructured Lipid Carriers Coated with Lauric Acid-Chitosan Oligomer for Dermal Delivery

8 citations , October 2020 in “Pharmaceutics”

Dutasteride-loaded nanoparticles coated with Lauric Acid-Chitosan show promise for treating hair loss due to their controlled release, low toxicity, and potential to stimulate hair growth.

research Engineered Dutasteride-Lipid Based Nanoparticle (DST-LNP) System Using Oleic and Stearic Acid for Topical Delivery

7 citations , January 2022 in “Bioengineering”

The formulation with oleic acid may be better for treating male pattern baldness.

research Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia

3 citations , September 2019 in “PLOS ONE”

Genetic variations affect dutasteride treatment response for male pattern hair loss.

research Administration of dutasteride in animal models of retinitis pigmentosa

December 2022 in “Acta Ophthalmologica”

Dutasteride potentially improves cell survival and reduces retinal damage in retinitis pigmentosa.

research Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors

16 citations , November 2018 in “The journal of pain/Journal of pain”

14,15-EET may help reduce poststroke pain by affecting certain brain proteins.

research Para rubber seed oil: The safe and efficient bio‐material for hair loss treatment

6 citations , November 2020 in “Journal of cosmetic dermatology”

Para rubber seed oil is a safe and effective treatment for hair loss.

research Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

1 citations , March 2021 in “F1000Research”

Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Bifunctional sodium hyaluronate microneedle patches integrating 5α-reductase and ROS regulation for boosted hair regeneration

July 2025 in “International Journal of Biological Macromolecules”

The microneedle patch boosts hair growth by reducing DHT and oxidative stress.

research Dissecting Cellulitis Presenting After Hair Restoration Surgery

November 2024 in “Cureus”

Early diagnosis and personalized treatment can prevent damage from dissecting cellulitis after hair restoration surgery.

A Pharmacovigilance Study of Drug-Reduced Male Semen Quality Based on the Food and Drug Administration Adverse Event Reporting System Database

research A pharmacovigilance study of drug‐reduced male semen quality based on the Food and Drug Administration adverse event reporting system database

June 2024 in “Andrology”

Some drugs can reduce male semen quality.

research Effets indésirables des médicaments sur la fertilité masculine : étude dans la base de données Vigibase

November 2017

Certain medications can negatively impact male fertility.

research Referee report. For: Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment [version 3; peer review: 2 approved]

January 2021 in “Faculty of 1000 Research Ltd”

Phytochemicals may offer safer alternatives to synthetic drugs for prostate cancer treatment.

research Mesotherapy in Androgenetic Alopecia: A Comprehensive Review of Active Ingredients, Protocols, and Clinical Efficacy

May 2025

Mesotherapy can improve hair growth in androgenetic alopecia but needs more research for standard use.

research Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction

July 2025 in “Foods”

Perilla seed extract may help prevent hair loss better than some standard treatments.

research Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids

8 citations , June 2020 in “The Journal of Clinical Endocrinology and Metabolism”

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

Study of Dutasteride Recovery in Organic Solvents Versus Dutasteride Dissolved in Human Blood Plasma

research Studi Recovery Dutasteride dalam Pelarut Organik terhadap Dutasteride Terlarut dalam Plasma Darah Manusia

August 2023 in “MPPKI (Media Publikasi Promosi Kesehatan Indonesia) : The Indonesia journal of health promotion”

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research Copious Pre‐Ejaculation: Small Glands—Major Headaches

9 citations , April 2007 in “Journal of Andrology”

Excessive pre-ejaculation can be treated with certain medications.

research Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

June 2021 in “F1000Research”

Plant-based compounds may offer safer prostate cancer treatment with fewer side effects.

research Forum

August 2012 in “Pharmaceutical Medicine”

The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

research Update Treatment of Male Androgenetic Alopecia

March 2021 in “Berkala Ilmu Kesehatan Kulit dan Kelamin”

The best treatment for male pattern baldness is a combination of topical minoxidil and oral finasteride.

research Th,-e mechanistic insights into the application of retinoids and possible adjunct therapeutic treatment to androgenic alopecia

October 2025 in “Annals of Medicine and Surgery”

Retinoids may improve hair growth in androgenic alopecia when used with other treatments.

Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

research Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis

37 citations , February 2014 in “Journal of Dermatology”

Valproic acid increases hair count in men with hair loss.

research Novel iron oxide nanocarriers loading finasteride or dutasteride: Enhanced skin penetration for topical treatment of alopecia

12 citations , July 2020 in “International Journal of Pharmaceutics”

Iron oxide nanoparticles improve skin penetration and drug release for hair loss treatment.

Effect of Solvent on Stereoselectivity in Pd/C (Type 39K)-Catalyzed Hydrogenation of Methyl 3-Oxo-4-Aza-5-Androstene-17-Carboxylate, a Key Intermediate for Finasteride and Dutasteride

research Effect of Solvent on Stereoselectivity in Pd/C (Type 39K)-Catalyzed Hydrogenation of Methyl 3-Oxo-4-aza-5-androstene-17-carboxylate, A Key Intermediate for Finasteride and Dutasteride

6 citations , July 2007 in “Organic Process Research & Development”

Alcoholic solvent improves selectivity in key intermediate for finasteride and dutasteride synthesis.

research Simultaneous Quantification of Dutasteride and Silodosin Using a Stability-Indicating RP-HPLC Approach

June 2024 in “International Journal of Pharmaceutical Quality Assurance”

The method accurately and quickly measures silodosin and dutasteride in mixtures.

Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation

research Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation

25 citations , March 2017 in “Archives of Dermatological Research”

Sinapic acid may help hair growth by activating a specific cell pathway.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.