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MILL molecules are unique immune proteins in mice that don't need TAP to appear on cell surfaces.

Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.

AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

Hoxc13 gene is essential for hair, nail, and papilla development.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

People with atopic dermatitis are more likely to develop other skin conditions due to shared genetics and immune pathways.

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

Ruxolitinib significantly improves multiple autoimmune conditions in APS-1 patients.

Polyomavirus A2 infection in newborn mice caused hair follicle tumors.

Thymosin β4 and VEGF are important for blood vessel formation in many organs.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Cathepsin L is essential for normal hair growth and development.

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Older age and related diseases increase COVID-19 risk, but anti-aging treatments might help.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Older skin has higher cancer risk due to inflammation and stem cell issues.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

A dog in Colorado was diagnosed with leishmaniasis, suggesting the disease might be present in the state.

Retinoids can prevent skin cancer in high-risk people but have side effects and require more research on dosing and effectiveness.

Diabetes can lead to blindness and skin problems, and managing blood sugar and blood pressure is crucial to prevent these complications.

New genes linked to ichthyosis were found, but there's still no cure; treatment options are improving.

Flumethasone causes wool shedding in Merino wethers, with recovery in about 60 days.

T-cell reconstitution after thymus transplantation can cause hair whitening and loss.

CD80CD86 deficiency causes hair loss by disrupting regulatory T cells.

A boy with severe immune deficiency and Epstein-Barr virus died from high-grade B-cell lymphoma.