Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit

September 2013 in “ Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry ”

Bowen Wu, Shiao-Pieng Lee, Hui-Chung Hsiao, Han Sheng Chiu, Chi-Yung Chen, Yee Hui Yeo, Herng‐Sheng Lee, Yawen Chen, Malvika Kaul, Hiroaki Kataoka, Michael D. Johnson, Jehng-Kang Wang, Chen‐Yong Lin

TLDR Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.

The study investigated the expression and activation of matriptase, a serine protease, in human hair follicles and sebaceous glands, finding it highly expressed in proliferative cells and activated in specific regions like the hair bulb and outer root sheath. Matriptase's role in cell proliferation and differentiation was highlighted, with its activity regulated by the inhibitor HAI-1. The matriptase-HGF-c-MET pathway was suggested to be crucial for hair follicle growth and function. Differences in matriptase expression between humans and rodents were noted, potentially explaining phenotypic differences in related conditions. The study concluded that matriptase is essential for early hair growth stages and maintaining the stem cell niche.

View this study on journals.sagepub.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Ichthyosis, Follicular Atrophoderma, And Hypotrichosis Caused By Mutations In ST14 Is Associated With Impaired Profilaggrin Processing

99 citations , October 2008 in “Journal of Investigative Dermatology”

Mutations in the ST14 gene cause skin and hair issues by disrupting important protein processing.

research Autosomal Recessive Ichthyosis With Hypotrichosis Syndrome: Further Delineation Of The Phenotype

55 citations , April 2008 in “Clinical Genetics”

A new mutation in the ST14 gene was found in a patient with ARIH syndrome, showing milder symptoms and no tooth issues.

research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

100 citations , May 2006 in “American Journal Of Pathology”

Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.

research Matriptase/MT-SP1 Is Required for Postnatal Survival, Epidermal Barrier Function, Hair Follicle Development, and Thymic Homeostasis

324 citations , May 2002 in “Oncogene”

research Identification of Clustered Cells in Human Hair Follicle Responsible for MMP-9 Gelatinolytic Activity: Consequences for the Regulation of Hair Growth

27 citations , June 2001 in “International Journal of Dermatology”

MMP-9 increase in hair follicles may lead to hair loss.

research Hair Cycle-Dependent Expression of Hepatocyte Growth Factor Activator, Other Proteinases, and Proteinase Inhibitors Correlates with the Expression of Hepatocyte Growth Factor in Rat Hair Follicles

33 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

research Correlation of Proteolytic Activities of Organ Cultured Intact Mouse Skin With Defined Hair Cycle Stages

28 citations , June 1994 in “Journal of Dermatological Science”

Proteolytic activity in mouse skin changes with hair cycle stages, peaking in early anagen.

research Growth Factors Specifically Alter Hair Follicle Cell Proliferation and Collagenolytic Activity Alone or in Combination

56 citations , December 1990 in “Differentiation”

Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.