256 citations
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October 2013 in “Nature Communications” Bioengineered lacrimal glands can restore tear production and protect eyes.
27 citations
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January 2012 in “Current Topics in Microbiology and Immunology” Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.
1 citations
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March 2011 in “Journal of Investigative Dermatology” Blocking RANK signaling might help treat metastatic melanoma, but more research is needed.
Fraser's Dolphin can heal skin wounds with minimal scarring, unlike humans.
10 citations
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May 2019 in “Seminars in Cell & Developmental Biology” Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.
21 citations
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January 2023 in “The International Journal of Developmental Biology” The Wnt signaling pathway is crucial for regeneration and could help advance human medicine.
21 citations
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April 2014 in “PLoS ONE” A rare gene variant causes hair and nail issues in a family.
2 citations
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January 2020 in “Libri Oncologici Croatian Journal of Oncology” PRP injections improve intestinal healing in rabbits with fewer complications than soaking.
76 citations
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February 2021 in “International Journal of Molecular Sciences” Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.
29 citations
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July 2014 in “PLoS ONE” Inactivating β-catenin is essential for chick retina regeneration.
1 citations
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December 2019 in “Archives of the Balkan Medical Union” Injecting platelet-rich plasma into the muscle layer improves intestinal healing and reduces adhesions.
53 citations
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April 2014 in “Experimental Dermatology” Wnt10b makes hair follicles bigger, but DKK1 can reverse this effect.
6 citations
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December 2021 in “PLoS Genetics” Polycomb Repressive Complex 2 is not needed for hair regeneration.
4 citations
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January 2020 in “Frontiers in Physiology” Good feather growth in poultry needs the right balance of proteins, amino acids, minerals, and vitamins.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
2 citations
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January 2022 in “Experimental Dermatology” GDNF signaling helps in hair growth and skin healing after a wound.
151 citations
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November 2014 in “Annual Review of Animal Biosciences” Feathers are crucial for understanding bird evolution, development, and have inspired biomimetic research.
January 2018 in “Stem cell biology and regenerative medicine” ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.
3 citations
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June 2023 in “MedComm” Stem cells and their exosomes show promise for repairing tissues and healing wounds when delivered effectively, but more research is needed on their tracking and optimal use.
759 citations
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February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
116 citations
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August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
8 citations
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June 2023 in “Acta Biochimica et Biophysica Sinica” rRSPO1 protein boosts hair growth by activating a key signaling pathway.
7 citations
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January 2018 in “Journal of Tissue Viability” An 80-year-old patient grew new hair on a wound, showing that elderly people can still regenerate hair.
72 citations
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July 2012 in “Journal of Investigative Dermatology” Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.
103 citations
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November 2014 in “Journal of Cell Biology” MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.
82 citations
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February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
72 citations
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April 2008 in “Organogenesis” Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.
67 citations
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December 2008 in “Developmental Biology” Msx2 and Foxn1 are both crucial for hair growth and health.
64 citations
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January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Human stem cells can help form hair follicles in mice.
47 citations
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May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology” The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.